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ProteomicsThe unphosphorylated form of the PAQosome core subunit RPAP3 binds ribosomal preassembly complexes to modulate ribosome biogenesis.
The PAQosome (Particle for Arrangement of Quaternary structure) is a twelve-subunit HSP90 co-chaperone involved in the biogenesis of several human protein complexes. Two mechanisms of client selection have previously been identified, namely the selective recruitment of specific adaptors and the diff...
ORGANISM(S): Homo sapiens (Human) 
2022-06-27 | PXD026647 | Pride
Ap-ms Ribosome preassembly factors Rpap3 Ribosome biogenesis Chaperone Ck2 phosphorylation Paqosome 
ProteomicsUpstream ORF-encoded ASDURF is a novel prefoldin-like subunit of the PAQosome
The PAQosome is an eleven-subunit chaperone involved in the biogenesis of several human protein complexes. We show that ASDURF, a recently discovered upstream open reading frame (uORF) in the 5’ UTR of ASNSD1 mRNA, encodes the twelfth subunit of the PAQosome. ASDURF, displays significant structural ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD015848 | Pride
Ap-ms Protein complex assembly Uorf Paqosome Small orf encoded peptide Chaperone Asdurf Bioid R2tp/pfdl Prefoldin 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047572 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
ProteomicsARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans
ARMC5 is an armadillo domain (ARM)-containing protein. We found that Armc5 KO mice had an increased incidence of neural tube defects (NTDs). ARMC5 is the substrate recognition component of a ubiquitin ligase that targets POLR2A, the largest subunit of RNA polymerase II (Pol II). Surprisingly, the ab...
ORGANISM(S): Homo sapiens (Human) 
2023-12-06 | PXD047533 | Pride
Myelomeningocele Armc5 Pol ii pool size Folh1 12 subunits of pol ii Polr2a-specific e3 Ubiquitin ligase Cullin 3 Neural tube defects 
UnknownThe gut microbiome of COVID-19 recovered patients returns to uninfected status in a minority-dominated United States cohort.
Not available
S-EPMC8205023 | biostudies-literature
ProteomicsPrioritisation, Identification, and Quantification of Emerging Contaminants in Recycled Textiles Using Non-Targeted and Suspect Screening Workflows by LC-ESI-HRMS
Recycled textile samples obtained in Sweden, 2021. Multi-residue extraction method used. Top-5 DDA + Inclusion List employed for MS2 acquisition. mzML files converted from raw data (ProteoWizard::msConvert).
ORGANISM(S): Na 
2024-06-29 | MSV000095185 | MassIVE
UnknownThe predictive ability of the 313 variant-based polygenic risk score for contralateral breast cancer risk prediction in women of European ancestry with a heterozygous BRCA1 or BRCA2 pathogenic variant.
Not available
S-EPMC8460445 | biostudies-literature
MetabolomicsNeuroactive metabolites and bile acids are altered in extremely premature infants with brain injury

The gut microbiome has been associated with pathological neurophysiological evolvement in extremely premature infants suffering from brain injury. The exact underlying mechanism and its associated metabolic signatures in infants are not fully understood. To decipher metab...

2023-12-30 | MTBLS7560 | MetaboLights
GenomicsMELARISK_SNP_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000122 | EGA
GenomicsMELARISK_MITF_geno
Genotypes at MITF E318K variant
EGAD00000000121 | EGA
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