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ProteomicsUpstream ORF-encoded ASDURF is a novel prefoldin-like subunit of the PAQosome
The PAQosome is an eleven-subunit chaperone involved in the biogenesis of several human protein complexes. We show that ASDURF, a recently discovered upstream open reading frame (uORF) in the 5’ UTR of ASNSD1 mRNA, encodes the twelfth subunit of the PAQosome. ASDURF, displays significant structural ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-25 | PXD015848 | Pride
Ap-ms Protein complex assembly Uorf Paqosome Small orf encoded peptide Chaperone Asdurf Bioid R2tp/pfdl Prefoldin 
UnknownTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Not available
S-EPMC10872554 | biostudies-literature
UnknownTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma.
Not available
S-EPMC10187264 | biostudies-literature
ProteomicsDIA-enabled discovery of alternative proteins (AltProts) in mouse heart development
In this project, we conducted an evaluation of mass spectrometry methods using mouse heart and HCT116 cell samples. The results demonstrated that the data-independent acquisition (DIA) approach outperformed data-dependent acquisition (DDA) in the identification of Altprot and canonical proteins. Sub...
ORGANISM(S): Mus musculus (Mouse) 
2025-01-17 | PXD045956 | Pride
Altorfs  mouse heart development  mass spectroemtry 
ProteomicsHuman medulloblastoma ASNSD1 uORF KO LC-MSMS
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
ORGANISM(S): Homo sapiens (Human) 
2024-01-03 | PXD046091 | Pride
Human Lc-msms Medulloblastoma Knockout 
GenomicsTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
EGAS00001007426 | EGA
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