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TranscriptomicsIntegration of high-resolution methylome and transcriptome analyses to dissect epigenomic changes in childhood acute lymphoblastic leukemia
B-cell precursor acute lymphoblastic leukemia (pre-B ALL) is the most common pediatric cancer. Although the genetic origin of the disease remains unclear, epigenetic modifications including DNA methylation are suggested to contribute significantly to leukemogenesis. We assessed the DNA methylation s...
ORGANISM(S): Homo sapiens 
2013-06-04 | E-GEOD-38235 | biostudies-arrayexpress
GenomicsBLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
EGAS00001001598 | EGA
TranscriptomicsGenome-wide assessment of imprinted expression in human cells
Parent-of-origin dependent expression of alleles, imprinting, has been suggested to impact a substantial proportion of mammalian genes. Its discovery requires allele-specific detection of expressed transcripts, but in some cases detected allelic expression (AE) bias has been interpreted as imprinti...
ORGANISM(S): Homo sapiens 
2011-01-21 | E-GEOD-26286 | biostudies-arrayexpress
Genomicsena-DATASET-BLUEPRINT-13-09-2016-12:21:58:649-53 - samples
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins (Bisulfite-Seq data).
EGAD00001002682 | EGA
TranscriptomicsNFkB perturbation followed by genome-wide allelic-expression data assessment
We developed a method that perturbs transcription factor followed by monitoring genome-wide allelic expression measurements in living cells. As a model for this novel approach, we chose the factor NFκB. We performed TNF-α induction coupled to inhibition of NFκB in LCLs followed by Allelic Express...
ORGANISM(S): Homo sapiens 
2014-11-03 | E-GEOD-61254 | biostudies-arrayexpress
GenomicsWP8_DNA_Methylation_450K_UCL
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
EGAD00010001025 | EGA
TranscriptomicsThe relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts [genotyping]
Background DNA methylation has long been known to play an essential role in the epigenetic regulation of gene expression and other cellular functions, and has been in some cases linked to genetic variation. While its presence near the transcription start site of a gene has been associated with red...
ORGANISM(S): Homo sapiens 
2013-12-11 | E-GEOD-52442 | biostudies-arrayexpress
ProteomicsProteomic data of ovary of OHSS model rat
The mass spectrometer was used to identify the labeled samples from electroacupuncture treated and Ovarian Hyper-stimulation Syndrome (OHSS) group. The ovarian proteins from four biological replicates in each group were extracted using the phenolic extraction method, iTRAQ labeling and quantitative ...
ORGANISM(S): Rattus Rattus 
2021-01-10 | PXD023493 |
ProteomicsI.e. mouse ovary palmitoylation protein LC-MSMS
To identify a role for protein palmitoylation in ovarian of DHEA-induced PCOS mice model. First, we used DHEA to induce a PCOS mice model，hematoxylin-eosin (H&E) staining sections form the ovaries of the Control and DHEA groups.The mice oral gavage with DHEA disrupted ovarian morphology,the estrous ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD028835 | Pride
I.e. mouse ovary， palmitoylation protein， lc-msms 
ProteomicsIdentification of H3 Lysine 4 Monomethylation Associated Proteins at Mammalian Enhancers
Enhancers act to regulate cell type specific gene expression by facilitating the transcription of target genes. In mammalian cells active or primed enhancers are commonly marked by monomethylation of Histone H3 at lysine 4 (H3K4me1) in a cell-type specific manner. Whether and how this histone modifi...
ORGANISM(S): Homo sapiens (Human) 
2018-10-23 | PXD007942 | Pride
And enhancers Monomethylation of histone h3 at lysine 4 (h3k4me1) Baf 
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