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ProteomicsPanomics reveals patient individuality as the major driver of colorectal cancer progression
Colorectal cancer (CRC) is one of the most prevalent cancers, with over one million new cases per year. Overall, prognosis of CRC largely depends on the disease stage and metastatic status. As precision oncology for patients with CRC continues to improve, this study aimed to integrate genomic, trans...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036434 | Pride
Tumor heterogeneity Multi-omics Colorectal cancer Patient individuality 
ProteomicsProtein profiling of WERI RB1 and etoposide resistant WERI ETOR reveals new insights to overcome topoisomerase inhibitor resistance in retinoblastoma
Chemotherapy resistance is one of the reasons for the loss of the eye in retinoblastoma (RB) pa-tients. RB chemotherapy resistance has been investigated in different cell culture models like WERI RB1. Furthermore, chemotherapy resistant RB subclones like the etoposide resistant WERI ETOR cell line h...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030924 | Pride
Chemotherapy resistance Mass spectrometry Weri rb1 Weri etor Retinoblastoma 
ProteomicsProteome dataset of cultured human bone marrow derived stromal (stem) cells, adipocytes and osteoblasts
Mesenchymal stromal stem cells (MSCs) gain increasing focus in the field of regenerative medicine due to their differentiational abilities into chondrocytes, adipocytes and osteoblastic cells. However, it is apparent that the transformation processes are extremely complex, cause cellular heterogenei...
ORGANISM(S): Homo sapiens (Human) 
2022-03-25 | PXD029900 | Pride
Dia Human Lc-msms 
ProteomicsMolecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations
Purpose: Chemotherapy is pivotal in the multimodal treatment of pancreatic cancer patients. In recent years, technical advances have developed experimental methods that unveiled a high degree of inter- and intratumoral heterogeneity in pancreatic cancer. We hypothesized that intratumoral heterogenei...
ORGANISM(S): Homo sapiens (Human) 
2023-09-19 | PXD042256 | Pride
Treatment response Pancreatic cancer Intratumor heterogeneity Chemotherapy Gemcitabine 
ProteomicsProteomic Remodeling During Tumor Cell-Induced Platelet Aggregation Unveils Metastatic Drivers in Colorectal Cancer
Colorectal cancer (CRC) is frequently associated with metastasis, resulting in high mortality rates. Platelets are known to play a crucial role in the metastatic cascade influencing tumor microenvironment remodeling, promoting cell transformation, facilitating metastatic niche formation, and shieldi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-02 | PXD062043 | Pride
Tcipa Proteomics Emt Dia-ms Platelets Metastasis Colorectal cancer 
ProteomicsCharacterization of the intratumoral heterogeneity using single cell-derived spheroids shows the involvement of metabolic changes during the metastatic cascade of colorectal cancer
Background: Colorectal cancer (CRC) stands as a significant contributor to cancer-related mortality globally. Approximately 90% of cancer mortality is due to distant metastasis. In the context of therapy, response rates can fluctuate significantly with approximately one-third of the patients experie...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD053393 | Pride
Intratumoral heterogeneity  single cells  spheroids  proteomics  aggresssiveness  metastatis  therapy resistance  intertumoral heterogeneity 
ProteomicsTargeting cancer-derived extracellular vesicles by combining CD147 inhibition and tissue factor pathway inhibitor for the management of urothelial cancer cells
Cancer cells release small particles or vesicles, which have the potency to induce cancer cells to spread and grow. In this study, we focused on two molecules presented by cell-derived vesicles that might promote cancer cells spread: a clotting protein and a cell surface protein. We found that vesic...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD044680 | Pride
Cancer-derived extracellular vesicles Urthelial cancer cells Cd147 Tissue factor Signaling 
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