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ProteomicsCX-MS of TFIIH and Def1 complex
The DNA damage response is an essential process for the survival of living cells. In a subset of stress-responsive genes in humans,Elongin controls transcription in response to multiple stimuli, such as DNA damage, oxidative stress, and heat shock. Yeast Elongin (Ela1-Elc1), along with Def1, is know...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-10-22 | PXD008223 | Pride
Stress response Transcription Rna polymerase ii Tfiih Def1 
TranscriptomicsTranscription profiling of S. cerevisiae TFIIH mutants treated with methyl methanesulfonate
Purpose of profiling experiment was to examine effects of a mutation of a subunit of TFIIH, ssl1p, which has ubiquitin ligase activity.,The whole complex has previously been shown to have both kinase and helicase activities. We wanted to see if 1) there were,general transcriptional defects with the...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-08 | E-GEOD-2343 | biostudies-arrayexpress
TranscriptomicsStably-paused genes revealed through inhibition of transcription initiation by the TFIIH inhibitor Triptolide
Transcription by RNA Polymerase II (Pol II) in metazoan is regulated in several steps, including preinitiation complex (PIC) formation, initiation, Pol II escape, productive elongation, cotranscriptional RNA-processing and termination. Genome-wide studies have demonstrated that the phenomenon of ...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-63314 | biostudies-arrayexpress
UnknownTfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.
Not available
S-EPMC3323989 | biostudies-literature
UnknownSubunit architecture of general transcription factor TFIIH.
Not available
S-EPMC3277522 | biostudies-literature
UnknownArchitecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH.
Not available
S-EPMC4560838 | biostudies-literature
ProteomicsSystematic mutagenesis identifies p52/Tfb2 residues required for XPB/Ssl2 function within TFIIH and genetic interactions with TFB6
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II Pre-Initiation Complex (PIC), TFIIH regulates the activity of the pol II enzyme in numerous ways. The TFIIH subunit XPB/Ssl2 i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD035576 | Pride
Mutagenesis Integrity Transcription start site Function P52/tfb2 Structure Rna polymerase ii transcription Gtf2h4 General transcription factor tfiih Tfb6 Xpb/ssl2 
ProteomicsStructure of transcription preinitiation complex engaged with the +1 nucleosome
The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed the PIC on different promoters, but did not address how the PIC assembles in chromatin. In the yeast Saccharomyces ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-03-11 | PXD029840 | Pride
+1 nucleosome Transcription Preinitiation complex Tfiih 
UnknownCovalent modification of a cysteine residue in the XPB subunit of the general transcription factor TFIIH through single epoxide cleavage of the transcription inhibitor triptolide.
Not available
S-EPMC4314353 | biostudies-literature
UnknownMicroRNA-27a regulates basal transcription by targeting the p44 subunit of general transcription factor IIH.
Not available
S-EPMC3102395 | biostudies-literature
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