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TranscriptomicsTranscriptome profiling of myeloid cell lines in Gelatin Methacrylate Hydrogels
Recapitulate the myeloid sarcoma gene expression using Gelma hydrogels in leukemic cell lines RNA-seq was performed onleukemic cell lines K562, Molm-13, PL-21, OCI-AML under two conditions (GelMA and control) to assess differential gene expression related to phenotype.
ORGANISM(S): Homo sapiens 
2025-09-01 | E-MTAB-15359 | biostudies-arrayexpress
MetabolomicsThe pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication

BACKGROUND: In all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate genome duplication prior to cell division. Failures in this regulation cause DNA damage with potentially disastrous consequences ...

2022-04-19 | MTBLS4415 | MetaboLights
ProteomicsA Robust Multiplex-DIA Workflow Profiles Protein Turnover Regulations Associated with Cisplatin Resistance and Aneuploidy
Measuring protein turnover is essential for understanding cellular biological processes and advancing drug discovery. The multiplex-DIA mass spectrometry (DIA-MS) approach, combined with dynamic SILAC labeling (pulse-SILAC, or pSILAC), has proven to be a reliable method for analyzing protein turnove...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD057632 | Pride
Aneuploidy Quantitative proteomics Protein turnover Dia Drug resistance Multiplex-dia Pulse silac 
UnknownWhite blood count, D-dimers, and ferritin levels as predictive factors of pulmonary embolism suspected upon admission in noncritically ill COVID-19 patients: The French multicenter CLOTVID retrospective study.
Not available
S-EPMC8239942 | biostudies-literature
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
ProteomicsA human-specific microRNA controls the timing of excitatory synaptogenesis
The development of neural circuits in the human cortex is considerably prolonged in comparison to non-human primates, a trait which contributes to the remarkable cognitive capacity of modern humans. In contrast to protein-coding genes, non-coding genes underwent a dramatic expansion during evolution...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD045809 | Pride
Neuron Development Human Ipsc 
ProteomicsThe proteome and phosphoproteome of acute stress in the mouse hippocampus (addendum phosphoproteomics males vs females)
This is an addendum for PXD024829 that was produced in the revision process. These additional data investigate the effect of forced swim stress on the phosphoproteome of male vs female mice immediately after stress exposure
ORGANISM(S): Mus musculus (Mouse) 
2022-02-09 | PXD029903 | Pride
Hippocampus Phosphoproteome Female Mus musculus Acute stress Male 
ProteomicsThe proteome and phosphoproteome of acute stress in the mouse hippocampus
The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure to trigger a strong stress response in mice, which transiently increa...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-09 | PXD024829 | Pride
Mouse Hippocampus Phosphoproteome Acute stress Proteome 
TranscriptomicsRNA-seq analysis of macrophages from normal and tumor-infiltrated omentum
Sequencing of mRNA from tissue-resident and tumor-associated macrophages in murine omentum display distinct transcriptional profile between macrophage subset of different origin
ORGANISM(S): Mus musculus 
2020-01-06 | E-MTAB-8141 | biostudies-arrayexpress
UnknownEndothelin receptor antagonism prevents hypoxia-induced mortality and morbidity in a mouse model of sickle-cell disease.
Not available
S-EPMC2276396 | biostudies-literature
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