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ProteomicsProteome-wide abundance profiling of yeast deletion strains for GET pathway members using sample multiplexing
The GET pathway is associated with post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) in yeast, as well as other eukaryotes. Moreover, dysfunction of the GET pathway has been associated with various pathological conditions. In this study, we used yeast delet...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-12-28 | PXD044391 | Pride
Faims Tmtpro Rts-ms3 Get pathway Isobaric tagging 
ProteomicsRegulated biogenesis and targeting of monotopic squalene monooxygenase requires the GET pathway
This study investigated get3 mutant yeast cell. Proteins of the GET pathway are involved in targeting of C-terminally anchored transmembrane proteins and protection against lipotoxicity. Get3 cells revealed an altered ergosterol production and susceptibility towards a sterol synthesis inhibiting dru...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-06-09 | PXD027705 | Pride
In-gel digestion Erg1 Terbinafine Lipotoxicity Lfq Squalene monooxygenase Get3 Get pathway 
ProteomicsRe-localization of components of the guided entry of tail-anchored proteins targeting pathway to cytosolic foci upon glucose starvation
Protein targeting is an essential step in the biogenesis of membrane proteins and the guided-entry of tail-anchored proteins (GET) pathway is a key targeting route to the endoplasmic reticulum. The adaptive response to cellular stress is multifaceted but a hallmark is the formation of membraneless o...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-02-25 | PXD054296 | Pride
Get pathway Membrane proteins 
GenomicsThe GET Pathway Modulates Azole Susceptibility through Sterol Metabolic Remodeling and Protein Trafficking in Filamentous Fungi
The GET Pathway Modulates Azole Susceptibility through Sterol Metabolic Remodeling and Protein Trafficking in Filamentous Fungi
PRJNA1456048 | ENA
TranscriptomicsDistinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
Medulloblastoma is a malignant brain tumor that occurs predominantly in children. Current risk stratification based on the clinical parameters is inadequate for accurate prognostication. In order to get a better understanding of medulloblastoma biology, miRNA profiling of medulloblastomas was carrie...
ORGANISM(S): Homo sapiens 
2012-10-27 | E-GEOD-41842 | biostudies-arrayexpress
TranscriptomicsThe GET Pathway Modulates Azole Susceptibility through Sterol Metabolic Remodeling and Protein Trafficking in Filamentous Fungi
Azole antifungals are widely used to control fungal infection, yet resistance mechanisms beyond drug efflux and target modification remain insufficiently understood. Here, we identified the Guided Entry of Tail-anchored proteins (GET) pathway as a conserved regulator of azole susceptibility in Neuro...
ORGANISM(S): Neurospora crassa 
2026-04-23 | GSE328637 | GEO
UnknownRegulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway.
Not available
S-EPMC9123286 | biostudies-literature
UnknownEndoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway.
Not available
S-EPMC3721280 | biostudies-literature
UnknownProteome-wide abundance profiling of yeast deletion strains for GET pathway members using sample multiplexing.
Not available
S-EPMC11045664 | biostudies-literature
UnknownER targeting of non-imported mitochondrial carrier proteins is dependent on the GET pathway.
Not available
S-EPMC7898604 | biostudies-literature
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