Sort   by:  
 Page size 
ProteomicsUSP11 deubiquitinates monoubiquitinated SPRTN to repair DNA-protein crosslinks
DNA-protein crosslinks (DPCs) are toxic DNA lesions that interfere with DNA metabolic processes such as replication, transcription, and recombination. SPRTN is a replication-coupled DNA-dependent metalloprotease that degrades proteins crosslinked to DNA to promote DPC repair. SPRTN function is tight...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD019923 | Pride
Deubiquitination Dpc Top1-ccs Dpc repair Monoubiquitinated sprtn Sprtn Usp11 
ProteomicsUSP1 expression driven by EWS-FLI1 transcription factor stabilizes Survivin and promotes Ewing sarcoma cell survival
Ewing sarcoma (EWS) is a malignant pediatric bone cancer. Most Ewing sarcomas are driven by EWS-FLI1 oncogenic transcription factor that plays roles in transcriptional regulation, DNA damage response, cell cycle checkpoint control, and alternative splicing. USP1, a deubiquitylase which regulates DNA...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041033 | Pride
Ews-fli1 Usp1 Survivin 
Sort   by:  
 Page size