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UnknownDevelopment of marker-free transgenic pigeon pea (Cajanus cajan) expressing a pod borer insecticidal protein.
Not available
S-EPMC8131364 | biostudies-literature
ProteomicsQuantitative cellular proteome analysis of Fetal- and Adult-Derived MLL-Rearranged Leukemia
Infant and adult MLL-rearranged (MLLr) leukemia represents a disease with few treatment options and a dismal prognosis. Here, we present an in-depth proteomic characterization of in utero-initiated and adult-onset MLLr leukemia in a mouse model of MLL-ENL-mediated leukemogenesis. We characterize ear...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042249 | Pride
Adult hematopoietic progenitor Tmtpro Mll-rearranged leukemia Fetal hematopoietic progenitor 
ProteomicsQuantitative proteome analysis to map the targets of small molecule UM171
Earlier we identified the protein degradation properties of small molecule UM171 (Subramaniam et al., 2020, Blood). Here we employed quantitative proteomics approach to map the global targets of UM171. Our study revealed multiple targets including the members of CoREST complex such as RCOR1 and LSD1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037999 | Pride
Um171 Protein degradation. Corest 
ProteomicsDefective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia
Despite the advanced understanding of disease mechanisms, the current therapeutic regimens fail to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-08 | PXD038318 | Pride
Aml Ribosome Lsc 
ProteomicsQuantitative secretome analysis of fetal and adult hematopoietic progenitors during leukemia initiation and its response to Fibulin and/or Fibronectin treatment.
We describe the proteomic composition of the secretome of fetal and adult hematopoietic progenitors during MLL-rearranged (MLLr) leukemia initiation as well as the pre-leukemic cells’ secretion response to the treatment with Fibulin (Fbln1) and/or Fibronectin (Fn1) using data-independent acquisition...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD049014 | Pride
Bone marrow Leukemia Secretome Extracellular Fetal liver Data-independent acquisition Hematopoietic progenitors 
ProteomicsSecretome and phosphoproteome analysis of THP-1 and KOPN-8 cells treated with Insulin-like growth factor 2.
We describe the secretome and phosphoproteome of human leukemia cell lines, THP-1 and KOPN-8, treated with Insulin-like growth factor 2 (IGF2) using data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD049016 | Pride
Leukemia Secretome Extracellular Data-independent acquisition Phosphoproteome Igf2 
ProteomicsQuantitative extracellular proteome analysis of fetal liver and adult bone marrow
We describe the proteomic composition of the extracellular environment of fetal and adult hematopoietic progenitors by data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042251 | Pride
Tissue interstitial fluid Bone marrow Fetal liver Data-independent acquisition Extracellular 
UnknownNoncanonical Decapentaplegic Signaling Activates Matrix Metalloproteinase 1 To Restrict Hedgehog Activity and Limit Ectopic Eye Differentiation in Drosophila.
Not available
S-EPMC5586372 | biostudies-literature
TranscriptomicsGenome wide expression profiling during spinal cord regeneration identifies comprehensive cellular responses in zebrafish
Among the vertebrates, teleost and urodele amphibians are capable of regenerating their central nervous system. We have used crush injury method on zebrafish spinal cord, which is a common mammalian mode of injury in spinal cord. To identify the molecular mechanisms of the underlying cellular events...
ORGANISM(S): Danio rerio 
2012-12-01 | E-GEOD-39295 | biostudies-arrayexpress
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