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ProteomicsTK SILACepedia - Reprogramming of the tyrosine kinase-regulated proteome in breast cancer by combined use of RNAi and SILAC quantitative proteomics
Tyrosine kinases (TKs) are central regulators in cellular activities and perturbations of TK signaling contribute to oncogenesis. However, less than half of the TKs have been thoroughly studied and a global functional analysis of their proteomic portrait is lacking. Here we conducted a combined appr...
ORGANISM(S): Homo sapiens (Human) 
2015-06-23 | PXD002065 | Pride
Silac tyrosine kinases breast cancer cell signaling 
ProteomicsLMTK3 Represses Tumour Suppressor-Like Genes through Chromatin Remodeling in Breast Cancer
LMTK3 is an oncogenic receptor tyrosine kinase (RTK) implicated in various types of cancer including breast, lung, gastric and colorectal. It is localized in different cellular compartments but its nuclear function has not been investigated thus far. We have mapped LMTK3 binding across the genome us...
ORGANISM(S): Homo sapiens (Human) 
2019-10-30 | PXD002399 | Pride
Lmtk3 chromatin breast cancer 
ProteomicsIdentification of LMTK3 protein by LC/MS/MS Analysis of 1D SDS PAGE Gel Bands
Identification of LMTK3 by LC/MS/MS. A plasmid encoding for full-length LMTK3 was overexpressed in MCF-7 breast cancer cells. Following antibody detection by WB, two bands of interest were seen at around 200 kDa and 150 kDa on the blotting membrane. Colloidal Coomassie (CCBB) staining was performed ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD001004 | Pride
Silac Lmtk3 Breast cancer Integrin b1 Grb2 
ProteomicsCell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping
Glioblastoma (GBM) is one of the most aggressive solid tumors for which treatment options and biomarkers are limited. Small extracellular vesicles (sEVs) produced by both GBM and stromal cells are central in the inter-cellular communication that is taking place in the tumor bulk. As tumor sEVs are a...
ORGANISM(S): Homo sapiens (Human) 
2019-08-08 | PXD014579 | Pride
Extracellular vesicles Glioblastoma Biomarkers 
ProteomicsLMTK3 inhibition affects microtubule stability
Elucidating the global proteomic alterations in MCF7 breast cancer cells, following pharmacological inhibition of LMTK3 using the C28 inhibitor
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD024644 | Pride
Breast cancer Nusap1 Kinase inhibitor Tubulin Lmtk3 
ProteomicsKinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma multiforme
Elucidating the global proteomic alterations in T98GRes glioblastoma cells, following knockdown of PANK4 in the presence or absence of temozolomide
ORGANISM(S): Homo sapiens (Human) 
2024-02-14 | PXD040871 | Pride
Temozolomide Pank4 knockdown T98gres glioblastoma cells 
OtherReprogramming of the tyrosine kinase-regulated proteome in breast cancer by combined use of RNAi and SILAC quantitative proteomics
Data from ProteomeXchange, PXD ID: PXD002065. File: GS-45.mzml. Published as part of Mol Cell Proteomics. 2015 Jun 18 . From the Abstract: {{i}} ... Tyrosine kinases (TKs) are central regulators in cellular activities and perturbations of TK signaling contribute to oncogenesis. However, less than h...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320016092 | GPMDB
Resource Reanalysis 
TranscriptomicsGenome wide screen of estrogen receptor α regulated microRNAs reveals a negative autoregulatory feedback loop
Estrogen receptor alpha (ERα) is a nuclear receptor linked to progression of the majority of human breast cancers. Following activation ERα regulates the transcription of target genes via DNA binding. Through a genome wide approach we have identified a subset of microRNAs (miRNAs or miRs) modulate...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-14685 | biostudies-arrayexpress
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