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Proteomicsmembrane substrates of gingipains
Porphyromonas gingivalis secretes cysteine proteases named gingipains which can cleave an array of proteins and importantly contribute to the development of periodontitis. In this study we focused on gingipain-exerted proteolysis at the cell surface of human gingival epithelial cells (telomerase imm...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD015679 | Pride
Protease Shedding Gingipain Anoikis Proteolysis 
UnknownRole of Acetyltransferase PG1842 in Gingipain Biogenesis in Porphyromonas gingivalis.
Not available
S-EPMC6256024 | biostudies-literature
UnknownMolecular docking analysis of imidazole quinolines with gingipain R from Porphyromonas gingivalis.
Not available
S-EPMC10504515 | biostudies-literature
ProteomicsGingipain transpeptidation - Porphyromonas gingivalis Gingipains Display Transpeptidation Activity
Porphyromonas gingivalis is a keystone periodontal pathogen that has been associated with autoimmune disorders. The cell surface proteases Lys-gingipain (Kgp) and Arg-gingipains (RgpA and RgpB) are major virulence factors and their proteolytic activity is enhanced by small peptides such as glycylgly...
ORGANISM(S): Homo sapiens (Human) 
2018-07-11 | PXD009950 | Pride
Transpeptidation Hemoglobin Gingipains Porphyromonas gingivalis 
UnknownPropeptide-mediated inhibition of cognate gingipain proteinases.
Not available
S-EPMC3677877 | biostudies-literature
UnknownGingipain regulates isoform switches of PD-L1 in macrophages infected with Porphyromonas gingivalis.
Not available
S-EPMC11947232 | biostudies-literature
GenomicsThe distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and 33277 are determined by the fimB allele and gingipain activity
The distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and 33277 are determined by the fimB allele and gingipain activity
PRJNA529240 | ENA
TranscriptomicsIdentification of bistable populations of Porphyromonas gingivalis that differ in epithelial cell invasion.
Bistable populations of bacteria give rise to two or more subtypes that exhibit different phenotypes. We have explored whether the periodontal pathogen, Porphyromonas gingivalis, exhibits bistable invasive phenotypes. Using a modified cell invasion assay, we show for the first time that there are tw...
ORGANISM(S): Porphyromonas gingivalis 
2010-08-31 | E-GEOD-23021 | biostudies-arrayexpress
TranscriptomicsThe distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and 33277 are determined by the fimB allele and gingipain activity
The genomes of P. gingivalis strains 33277 and 381 are highly related phylogenetically. However, 33277 displays a reduced capacity to stimulate HEK cell TLR2-dependent signaling and THP-1 cell-dependent IL-1β production compared to 381, suggesting strain-specific differences in the expression of one...
ORGANISM(S): Porphyromonas gingivalis 381 Porphyromonas gingivalis ATCC 33277 
2019-09-30 | GSE128899 | GEO
UnknownTreatment of Porphyromonas gulae infection and downstream pathology in the aged dog by lysine-gingipain inhibitor COR388.
Not available
S-EPMC6990966 | biostudies-literature
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