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ProteomicsPCT-assisted mass spectrometric quantification of gingival tissue reveals dynamics of protein synthesis during initiation and progression of inflammatory disease
Understanding the progression of periodontal destruction is at the forefront of periodontal research. Therefore, we aimed to capture the dynamics of gingival tissue proteome during initiation and progression of an experimental periodontitis developed by placing silk ligatures on the second molars of...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD014608 | Pride
Experimental periodontitis Gingival tissue Pressure cycling technology Label-free quantitation Proteome Gingival inflammation Periodontitis Pct 
ProteomicsProteome mapping of human gingival tissue in health and disease
Gingival tissue proteome is at the forefront of the periodontal research, yet have been hampered by lack of sufficient tissue-extraction methods. Using an emerging technology for tissue homogenization, pressure cycling technology (PCT), we characterize the gingival tissue proteomic profiles of both ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD018029 | Pride
Pressure cycling technology Gingival tissue proteome Chronic periodontitis 
ProteomicsComparative Proteomics of Tissue and Gingival Crevicular Fluid in Periodontitis
Periodontitis is an inflammatory condition affecting periodontal tissues, such as the gingiva and alveolar bone, surrounding the teeth. However, previous research has focused on analyzing a single sample type, such as tissue, blood, or gingival crevicular fluid (GCF), which may limit the comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD054953 | Pride
Proteomics Periodontitis Neutrophil Gcf Systemic inflammation 
UnknownProteome and Microbiome Mapping of Human Gingival Tissue in Health and Disease.
Not available
S-EPMC7566166 | biostudies-literature
UnknownPressure Cycling Technology Assisted Mass Spectrometric Quantification of Gingival Tissue Reveals Proteome Dynamics during the Initiation and Progression of Inflammatory Periodontal Disease.
Not available
S-EPMC7033018 | biostudies-literature
ProteomicsGingival exudatome dynamics implicates inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis
Complement inhibition has been successfully used to treat periodontitis in animal models. However, proteome studies that investigated the role of complement C3 were missing. The objective of this study was to characterize local tissue exudate (“gingival crevicular fluid”; GCF) changes after administ...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2018-08-17 | PXD009502 | Pride
C3 inhibitor Gcf Periodontitis Macaca fascicularis 
UnknownGingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis.
Not available
S-EPMC6128774 | biostudies-literature
Proteomicsmembrane substrates of gingipains
Porphyromonas gingivalis secretes cysteine proteases named gingipains which can cleave an array of proteins and importantly contribute to the development of periodontitis. In this study we focused on gingipain-exerted proteolysis at the cell surface of human gingival epithelial cells (telomerase imm...
ORGANISM(S): Homo sapiens (Human) 
2020-04-28 | PXD015679 | Pride
Protease Shedding Gingipain Anoikis Proteolysis 
UnknownInvestigation of the Cell Surface Proteome of Human Periodontal Ligament Stem Cells.
Not available
S-EPMC4989088 | biostudies-literature
ProteomicsHs_hGF_hPDLF
LC-MS/MS of gingiva and Periodontal ligaments
ORGANISM(S): Homo Sapiens (human) 
2013-12-31 | PAe004989 | PeptideAtlas
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