Sort   by:  
 Page size 
MetabolomicsMetabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens
Not available
ORGANISM(S): Mus musculus 
ST001256 | MetabolomicsWorkbench
ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. A three-phase prote...
ORGANISM(S): Homo sapiens (Human) 
2021-03-14 | PXD019945 | Pride
Pbmc Glucocorticoid Proteomics Dexamethasone Biomarker 
ProteomicsIdentification of candidate circulating glucocorticoid response biomarkers in humans using a proteomic approach
Context Glucocorticoids used in pharmacological doses for the treatment of a variety of medical conditions, and endogenous glucocorticoid excess – Cushing’s syndrome, may result in several adverse effects, but currently there is no clinically useful biomarker of glucocorticoid activity. Objective T...
ORGANISM(S): Homo Sapiens 
2021-03-15 | PXD019972 | panorama
TranscriptomicsThe NOD/SCID Xenograft Model Provides Clinically-Relevant Insights into Glucocorticoid-Induced Gene Expression in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia
Introduction. Glucocorticoids are critical drugs used to treat acute lymphoblastic leukemia, and response to glucocorticoids is highly predictive of outcome. Here we report a study evaluating the NOD/SCID xenograft mouse model to investigate glucocorticoid-induced gene expression. Methods. NOD/SCID ...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lens epithelial cells to examine glucocorticoid induced changes
Prolonged use of glucocorticoids can lead to the formation of a cataract, however the mechanism is not known. We recently reported the presence of the functional glucocorticoid receptor in immortalized cultured mammalian lens epithelial cells (Gupta & Wagner, Invest Ophthalmol Vis Sci 2003), but the...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-3040 | biostudies-arrayexpress
GenomicsGlucocorticoid receptor profiling in U2OS cells expressing GRalpha or GRgamma isoform
To determine whether insertion of a single amino acid had an effect on Glucocorticoid receptor (GR) occupancy, we performed ChIP-seq of GRalpha and GRgamma in the same U2OS osteosarcoma cell lines, upon glucocorticoid treatment. These assays are also part of submission E-MTAB-2955
ORGANISM(S): Homo sapiens 
2014-08-08 | E-MTAB-2731 | biostudies-arrayexpress
TranscriptomicsRegulation of synovial DKK1 expression by local glucocorticoid metabolism in inflammatory arthritis
Inflammatory arthritis is associated with bone loss and fractures due to abnormal bone remodelling. Bone remodelling is 'uncoupled' with bone resorption increased and bone formation suppressed. These changes resemble those seen in patients treated with therapeutic glucocorticoids, and in both of the...
ORGANISM(S): Homo sapiens 
2012-04-24 | E-GEOD-37520 | biostudies-arrayexpress
GenomicsGlucocorticoid Receptor and Androgen Receptor DNA binding in LREX'
LREX' are a LnCAP/AR subline with natural expresison of the glucocorticoid receptor. We used the model to compare the AR and GR cistromes in prostate tissue. We determined the GR cistrone in the presence of Dex (100nM) treatment and the AR cistrome in the presene of DHT (1nM) treatment.
ORGANISM(S): Homo sapiens 
2013-12-27 | E-GEOD-51497 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid Resistance Gene Profiling in T-ALL Cell Lines
Baseline glucocorticoid resistance profiles were measured in a panel of 15 paediatric T-Cell acute lymphoblastic leukaemia cell lines and correlated with Affymetrix Gene expression to identify genes and pathways associated with drug resistance in T-ALL. The cell lines' resistance to Methylprednisolo...
ORGANISM(S): Homo sapiens 
2012-07-09 | E-MTAB-1208 | biostudies-arrayexpress
TranscriptomicsSexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids
Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory horm...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-13461 | biostudies-arrayexpress
Sort   by:  
 Page size