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TranscriptomicsHes1 and Liver Glucocorticoid Signaling
To investigate the role of HES1 during glucocorticoid signaling in the liver, we employed whole-genome microarray expressions in liver mRNA extracted from control and Hes1-liver knockout male mice (HESKOL) that had been adrenalectomized to remove endogenous glucocorticoids. RNA isolated from the liv...
ORGANISM(S): Mus musculus 
2014-01-08 | E-GEOD-52106 | biostudies-arrayexpress
ProteomicsConvergent effects of glucocorticoid stress hormones and amyloid beta in human primary olfactory neuroepithelial
Stressful life events and glucocorticoid (stress) hormones appear to increase risk of Alzheimer’s disease and hasten its progression, but the reasons for this remain unclear. One contributor may be intracellular interactions between amyloid β (Aβ), an early pathological hallmark of Alzheimer’s disea...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD056362 | Pride
Alzheimer’s disease Glucocorticoid Immune Stress Olfactory neuroepithelium 
TranscriptomicsSexual Dimorphic Regulation of Liver Gene Expression by Glucocorticoids
Males and females exhibit differences in the incidence of many major diseases including auto-immune diseases, hepatocellular carcinoma, diabetes, and osteoporosis, which all have important inflammatory components in their etiology. Glucocorticoids are the primary physiological anti-inflammatory horm...
ORGANISM(S): Rattus norvegicus 
2010-10-01 | E-GEOD-13461 | biostudies-arrayexpress
TranscriptomicsRole of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling
In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser1...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-28912 | biostudies-arrayexpress
TranscriptomicsHes1 and Glucocorticoid Signaling in Bone Sarcoma Cells
To investigate the role of HES1 during glucocorticoid signaling in bone sarcoma cells (U2OS-GR cells) , we employed whole-genome microarray expressions in mRNA extracted from control U2OS-GR and Hes1-overexpressed U2OS-GR cells. RNA isolated from control U2OS-GR and Hes1-overexpressed U2OS-GR cells...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52727 | biostudies-arrayexpress
TranscriptomicsCryptochromes mediate rhythmic repression of the glucocorticoid receptor
The circadian transcriptional repressors cryptochromes 1 (Cry1) and 2 (Cry2) interact with the C-terminus of the glucocorticoid receptor (GR) and are required for transrepression in response to the synthetic GR ligand dexamethasone (Dex) in mouse embryonic fibroblasts. Dex induction of many genes w...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-24469 | biostudies-arrayexpress
TranscriptomicsThe effect of GW3965 and dexamethasone on gene expression of rat livers
GLUCOCORTICOIDS are steroid hormones that strongly influence intermediary carbohydrate metabolism by increasing the transcription rate of glucose-6-phosphatase (G6Pase) a key enzyme of gluconeogenesis, and suppress the immune system which makes them one of the most important therapeutic agents in th...
ORGANISM(S): Rattus norvegicus 
2012-04-01 | E-GEOD-29912 | biostudies-arrayexpress
no omics definedTranscription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series
Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanis...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6711 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid effect on mRNA translation in childhood acute lymphoblastic leukemia
Glucocorticoids (GCs) are a central component in treating childhood acute lymphoblastic leukemia (chALL). They mainly act via regulating gene transcription. However, control of mRNA translation by GC has never been assessed systematically. In our research, T- and precursor B-ALL cells were cultured ...
ORGANISM(S): Homo sapiens 
2013-12-03 | E-GEOD-48680 | biostudies-arrayexpress
TranscriptomicsHES1 Is a Master Regulator of Glucocorticoid Receptor-Dependent Gene Expression
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-52784 | biostudies-arrayexpress
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