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Orb weavers place aggregate glue on a stretchy capture spiral, whereas cobweb weavers add it to the ends of strong, stiff fibers, called gumfoot lines. We describe the quantitative proteomics of the aggregate glues of two cobweb weaving species, the Western black widow, Latrodectus hesperus, and the...
ORGANISM(S): Latrodectus hesperus (Western black widow spider) Parasteatoda tepidariorum 
2022-02-17 | PXD025685 | Pride
The molecular characterization of samples from works of art can provide valuable insights into the composition of ancient restoration materials and their conservation state. Here, we present a novel experimental protocol for the molecular characterization of a specific adhesive used in historical pa...
ORGANISM(S): Bos taurus (Bovine) linum usitatissimum Oryctolagus cuniculus (Rabbit) Triticum aestivum (Wheat) Secale cereale Acipenser sturio 
2024-10-17 | PXD051480 | Pride
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Discovery of a covalent molecular glue degrader that covalently interacts with UBE2D and engages in molecular glue interactions with NFKB1
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039924 | Pride
Using proteomics, we documented the glue composition in two congeners that live in different environments, Argiope argentata (dry southwest US) and A. trifasciata (humid southeast US). The viscoelastic protein cores of A. argentata droplets comprised a smaller portion of droplet volume than did thos...
ORGANISM(S): Argiope trifasciata Argiope argentata 
2023-07-13 | PXD037612 | Pride
The majority of clinical degraders utilize an immunomodulatory imide drug (IMiD)-based derivative, that directs their target to the E3 ligase receptor Cereblon (CRBN), however, identification of IMiD molecular glue substrates has remained underexplored. To tackle this, we design human CRBN construct...
ORGANISM(S): Homo sapiens (Human) 
2024-12-06 | PXD057393 | Pride
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
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