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GenomicsTRI-611, a selective, brain-penetrant molecular glue degrader of ALK
TRI-611, a selective, brain-penetrant molecular glue degrader of ALK
PRJNA1459258 | ENA
ProteomicsChemoproteomics-Enabled Discovery of a Covalent Molecular Glue Degrader
Discovery of a covalent molecular glue degrader that covalently interacts with UBE2D and engages in molecular glue interactions with NFKB1
ORGANISM(S): Homo sapiens (Human) 
2023-02-08 | PXD039924 | Pride
Molecular glue degraders 
UnknownChemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB.
Not available
S-EPMC10121878 | biostudies-literature
ProteomicsA novel HERC4-dependent glue degrader targeting STING
Stimulator of interferon genes (STING) is a central component of the pathway sensing the presence of cytosolic nucleic acids, having a key role in type I interferon innate immune response. Localized at the endoplasmic reticulum (ER), STING becomes activated by cGAMP, which is generated by the intrac...
ORGANISM(S): Homo sapiens (Human) 
2023-06-22 | PXD040291 | Pride
Targeted protein degradation Herc4 Glue degrader Tpd Sting 
UnknownSJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.
Not available
S-EPMC9377019 | biostudies-literature
UnknownThe CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Not available
S-EPMC7486275 | biostudies-literature
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
ProteomicsA cereblon-based (CRBN) glue degrader of NEK7 regulates NLRP3 inflammasome in a context-dependent manner
Aberrant NLRP3 inflammasome activation is linked to many inflammatory diseases, driving the search for therapeutics inhibiting this pathway. NEK7 is proposed to mediate NLRP3 inflammasome assembly and activation by bridging adjacent NLRP3 subunits. Hence, reduction of NEK7 protein may block NLRP3 ac...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-18 | PXD057229 | Pride
Molecular glue degrader Inflammation Nek7 Nlrp3 inflammasome Crbn 
UnknownSimple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders.
Not available
S-EPMC7354697 | biostudies-literature
TranscriptomicsTRI-611, a selective, brain-penetrant molecular glue degrader of ALK
Tyrosine kinase inhibitors (TKIs) targeting Anaplastic Lymphoma Kinase (ALK) have transformed the treatment landscape of ALK fusion-positive non-small cell lung carcinoma (NSCLC), but limited options for patients who progress on approved TKIs highlight a continued need for an orthogonal therapeutic ...
ORGANISM(S): Homo sapiens 
2026-08-01 | GSE329452 | GEO
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