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Metabolomics1H-NMR-based metabolomic analysis identifies disrupted glutamate metabolism as distinct serum signature in Parkinson’s disease patients
Using High-Performance Liquid Chromatography, we recently demonstrated a complex dysregulation of the glutamate NMDA receptor-stimulating amino acids in the brain, CSF and serum of Parkinson’s disease (PD) experimental models and patients. Here, we investigate the serum metabolomic profile in the sa...
2024-11-08 | MTBLS10958 | MetaboLights
MetabolomicsInvestigating TCA concentrations in mice muscle tissue lacking insulin receptors and IGF-1 receptors
Not available
ORGANISM(S): Mus musculus 
ST000512 | MetabolomicsWorkbench
MetabolomicsInvestigating large scale metabolomics in mice tissue lacking insulin receptors and IGF-1 receptors
Not available
ORGANISM(S): Mus musculus 
ST000551 | MetabolomicsWorkbench
ProteomicsIdentification of glutamate receptor delta-1 interactome at synapses.
In this project, we have investigated the interactome of the glutamate receptor delta-1 (GluD1) in developing synapses in mice. GluD1 is a member of the delta subfamily of ionotropic glutamate receptors widely expressed in the brain. It behaves as a postsynaptic organizer by engaging in trans-synapt...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-06 | PXD010373 | Pride
Synapse Neuron Glutamate receptor Brain Grid1 Mouse 
ProteomicsTemporal quantitative proteomics of mGluR-induced protein translation and phosphorylation in neurons
At neuronal synapses, activation of group I metabotropic glutamate receptors (mGluR1/5) triggers a form of long-term depression (mGluR-LTD) that relies on new protein synthesis and the internalization of AMPA-type glutamate receptors. Dysregulation of these processes has been implicated in the devel...
ORGANISM(S): Rattus Norvegicus 
2020-10-27 | PXD020777 | panorama
ProteomicsProtein networks associated with native metabotropic glutamate 1 receptors (mGlu1) in the mouse cerebellum.
To identify novel mGlu1-associated protein complexes in the mouse cerebellum, we used an unbiased tissue-specific proteomic approach, namely co-immunoprecipitation followed by liquid chromatography/tandem mass spectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD040886 | Pride
Glutamate receptors  cerebellum  kctd12  immunoprecipitation  proteomics 
UnknownGlutamate, glutamate receptors, and downstream signaling pathways.
Not available
S-EPMC3805900 | biostudies-literature
ProteomicsDynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in exci...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-07 | PXD008353 | Pride
Neuron Phosphoproteome Proteome Excitotoxicity 
ProteomicsArrestin engagement of the metabotropic glutamate receptor mGlu5
Phosphorylation sites identified at the C-terminus of mGlu5 by mass spectrometry analysis
ORGANISM(S): Homo Sapiens 
2026-04-01 | PXD076479 |
GenomicsGlutamate Ionotropic Kainate Receptors as Therapeutic Targets in Enzalutamide-Resistant and Neuroendocrine Prostate Cancer
Glutamate Ionotropic Kainate Receptors as Therapeutic Targets in Enzalutamide-Resistant and Neuroendocrine Prostate Cancer
PRJNA1478880 | ENA
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