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ProteomicsProteome of Burkholderia cenocepacia H111 in aerobic and micro-oxia condition
Using a discovery shotgun proteomics approach, the expressed proteome of Burkholderia cenocepacia (strain H111) under aerobic (21% oxygen) and micro-oxic (0.5% oxygen) conditions was analyzed. B.cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering fr...
ORGANISM(S): Burkholderia cenocepacia H111 
2013-07-18 | PXD000270 | Pride
Shotgun lc-ms/ms Cystic fibrosis Burkholderia cepacia complex (bcc) Biofilm 
ProteomicsProteomics Analysis of Burkholderia Kirkii
Protein extract from symbiontic Burkholderia Kirkii (3 replicates: A,B,C): each fractionated by SDS-PAGE and digested using Trypsin, each fraction measured twice in LC-MSMS, once in discovery mode and once using an exclusion list based on first run. Mass spectra were searched against a protein seque...
ORGANISM(S): Candidatus Burkholderia kirkii 
2013-07-18 | PXD000147 | Pride
Burkholderia kirkii 
ProteomicsA proteome analysis of Bradyrhizobium japonicum USDA 110 grown in minimal medium containing arabinose suggests that oxalate oxidation extends the arabinose degradation branch via glycolaldehyde.
B. japonicum cells were grown either in minimal medium (BVM) with L-arabinose as carbon and energy source or in complete medium (PSY) containing L-arabinose. Proteins extracted from three replicates of B. japonicum cells grown in complex and minimal medium with L-arabinose until mid-exponential pha...
ORGANISM(S): Bradyrhizobium japonicum USDA 110 
2014-01-30 | PXD000487 | Pride
Lc-msms Rhizobia Oxalotrophy Psy medium Oxalate Bvm medium 
ProteomicsComplete Expressed Proteome of Bartonella Henselae
Using a discovery proteomics approach, the expressed proteome of Bartonella henselae, a Gram-negative prokaryotic model organism was exhaustively studied under two conditions that mimic those encountered in different hosts. Using the analysis-driven experimentation (ADE) feedback-loop strategy, w...
ORGANISM(S): Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) 
2013-07-18 | PXD000153 | Pride
Complete membrane proteome Bartonella henselae Complete proteome Ade 
MetabolomicsEpistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...
2021-03-29 | MTBLS2205 | MetaboLights
ProteomicsSLC15A4 (PHT1) interaction proteomics
Human genetics and mouse models provide compelling evidence for the involvement of SLC15A4 in endosomal TLR activation. To gain an understanding of the molecular mechanism, we set out to identify its binding partners by interaction proteomics. TAP-MS/MS analysis of different SLC15A4 protein variants...
ORGANISM(S): Homo sapiens (Human) 
2020-05-14 | PXD014254 | Pride
Human Slc Tap Cxorf21 Lc-ms/ms 
MetabolomicsMetabolic mapping of the entire human solute carrier superfamily

Solute carrier (SLC) transporters govern most of the chemical exchange across cellular membranes and are integral to metabolic regulation, which in turn is linked to cellular function and identity. Despite their key role, individual functions of the SLC superfamily members were not evaluated syst...

2025-04-08 | MTBLS10077 | MetaboLights
Proteomicss54-dependent response to nitrogen limitation and virulence in Burkholderia cenocepacia H111
Using a discovery shotgun proteomics approach, the expressed proteome of Burkholderia cenocepacia (strain H111) was analyzed under normal and starved nitrogen growth conditions. B. cenocepacia is an opportunistic human pathogen that is particularly problematic for patients suffering from cystic fibr...
ORGANISM(S): Burkholderia cenocepacia H111 
2015-05-05 | PXD001924 | Pride
Cystic fibrosis Burkholderia cepacia complex (bcc) Biofilm 
MetabolomicsGain-of-function genetic screens in human cells identify SLC transporters overcoming environmental nutrient restrictions

Solute carrier (SLC) transporters control fluxes of nutrients and metabolites across membranes and thereby represent a critical interface between the microenvironment and cellular and subcellular metabolism. Because of substantial functional overlap, the interplay and relative contributions of SL...

2022-09-20 | MTBLS4268 | MetaboLights
MetabolomicsMetabolic mapping of the human solute carrier superfamily

Solute carrier (SLC) transporters govern most of the chemical exchange across cellular membranes and are integral to metabolic regulation, which in turn is linked to cellular function and identity. Despite their key role, individual functions of the SLC superfamily members were not evaluated syst...

2025-07-22 | MTBLS11393 | MetaboLights
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