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MetabolomicsSeminal lipid depletion and gut microbiome–metabolome alterations in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism: an integrated multi-omics study
This study investigated seminal plasma lipid alterations and gut microbiome–metabolome changes in men with gonadotropin-treated idiopathic hypogonadotropic hypogonadism. Seminal plasma metabolomics, fecal metagenomic sequencing, and fecal metabolomics were performed in patients and healthy controls....
2026-07-20 | MTBLS15080 | MetaboLights
TranscriptomicsThe ISWI ATPase Snf2L is required for superovulation and regulates Fgl2 in differentiating mouse granulosa cells
We investigate the role of Snf2l in ovaries by characterizing a mouse bearing an inactivating deletion on the ATPase domain of Snf2l (Ex6DEL). Snf2l mutant mice produce significantly fewer eggs than control mice when superovulated. Thus, gonadotropin stimulation leads to a significant deficit in sec...
ORGANISM(S): Mus musculus 
2013-05-01 | E-GEOD-42997 | biostudies-arrayexpress
TranscriptomicsGranulosa cell responses to Gonal vs Menopur
Goal of the experiment: To examine differential gene expression in granulosa cells of women undergoing ovarian stimulation with either recombinant human follicle stimulating hormone or purified human menopausal gonadotropin for in vitro fertilization. Brief description of the experiment: The stud...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-16523 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse leydig tumor cell line stimulated with either human chorionic gonadotropin alone or with bisphenol A, an endrocrine disrupting chemical
A mouse leydig tumour cell line (mLTC-1) was grown in culture and stimulated with either human chorionic gonadotropin (hCG, 10 ng/ml) alone or hCG & bisphenol A (BPA, an endrocrine disrupting chemical, 10 uM) for three hours. Cells from triplicate plates were harvested, RNA extracted, labelled and ...
ORGANISM(S): Mus musculus 
2008-01-01 | E-MIMR-282 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of the transcriptome in the primate corpus luteum during chorionic gonadotropin administration simulating early pregnancy.
To explore chorionic gonadotropin (CG)-regulated gene expression in the primate corpus luteum (CL), adult female rhesus macaques were treated with a model of simulated early pregnancy (SEP). Total RNA was isolated from individual CL and hybridized to AffymetrixM-bM-^DM-" GeneChip Rhesus Macaque Geno...
ORGANISM(S): Macaca mulatta 
2011-11-21 | E-GEOD-25335 | biostudies-arrayexpress
TranscriptomicsExpression data from progesterone receptor knockout versus heterozygous mouse oviducts
The oviducts play a critical role in gamete and embryo transport, as well as supporting fertilization and early embryo development. Progesterone receptor (PGR) is a transcription factor highly expressed in oviductal cells, while it’s activating ligand, progesterone (P4), surges to peak levels as ...
ORGANISM(S): Mus musculus 
2014-06-16 | E-GEOD-51499 | biostudies-arrayexpress
ProteomicsComparing different pregnant mare serum gonadotropin products: surprising differences in protein content and a new sialic acid O-acetylation
Equine chorionic gonadotropin (eCG) is a widely used hormone to synchronize the female cycle and induce estrusestruses in livestock breeding. eCG is a heterodimeric glycoprotein composed of non-covalently linked α- and β-chains whose glycosylation profiles determine the in vivo activity of the hormo...
ORGANISM(S): Equus caballus (Horse) 
2025-05-06 | PXD042535 | Pride
O-acetylation Equine chorionic gonadotropin (ecg) and lutropin Pregnant mare serum gonadotropin (pmsg) Sulfation 
ProteomicsReverse-Phase High-Performance Liquid Chromatography/Mass Spectrometry (RP-LC-MS/MS, Label-Free Method) for Component Analysis of Gonadotropin Drugs
In assisted reproductive technology (ART), controlled ovarian hyperstimulation (COS) plays an important role in guiding treatment progress and determining success. Many ovulation-inducing agents are used in this process, including human menopausal gonadotropin (HMG), recombinant follicle-stimulating...
ORGANISM(S): Homo Sapiens 
2025-12-31 | PXD072543 |
ProteomicsIdentification of protein complexes in Gonadotropin signaling using discovery proteomics
We utilized discovery proteomics to identify putative factors that are recruited to the GnRH-responsive promoter regions of gonadotropin β genes (Egr1 and cFos). We also used this approach to identify proteins that associate with immediate early genes that regulate LHβ and FSHβ.
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD075636 | Pride
Gonadotropins 
TranscriptomicsComparison of granulosa cells from WT and Inha KO mice following gonadotropin stimulation
Inhibin α knockout (Inha-/-) female mice develop sex cord-stromal ovarian cancer with complete penetrance and previous studies demonstrate that the pituitary gonadotropins [follicle stimulating hormone (FSH) and luteinizing hormone (LH)] are influential modifiers of granulosa cell tumor development ...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-20466 | biostudies-arrayexpress
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