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ProteomicsQuantitative Proteomic Study Unmasks Fibrinogen Pathway in Polycystic Liver Disease
(1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism is currently unknown and the PLD treatment is limited to liver transplantat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031253 | Pride
Pld  swath  quantitative proteomics  therapeutic targets 
ProteomicsLinking First-Pass Reperfusion Success to Proteomic Markers in Large and Medium Vessel Ischemic Stroke
Mechanical thrombectomy (MT) has improved disability outcomes after ischemic stroke (IS), mainly when the so-called modified first-pass effect (mFPE) is achieved. This study aims to explore the proteomic profiling of thrombi composition in those patients who achieved mFPE. A prospective study was co...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD066161 | Pride
Biological pathways  ischemic stroke  mechanical thrombectomy  proteomics  thromboinflammation 
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
ProteomicsA comparative proteomic, transcriptomic and glycomic analysis of extracellular vesicle isolation techniques highlights ExoGAG efficiency for a more complete identification of breast milk molecular signaling pathways
Background: Human milk (HM) is the earliest form of extrauterine communication between mother and infant. We recently showed a functional characterization of HM, unmasking the molecular mechanisms related to EV signaling and its functional role in prematurity. In that study, we identified the need t...
ORGANISM(S): Homo sapiens (Human) 
2025-10-13 | PXD060683 | Pride
Glycomics. Proteomics Extracellular vesicles Human milk Transcriptomics Isolation method 
UnknownDetection of balance in the elderly under the influence of stress (DEPIE): A cross-sectional study protocol.
Not available
S-EPMC12843555 | biostudies-literature
TranscriptomicsMultiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
Epidermal growth factor (EGF) is a key regulatory growth factor activating a myriad of processes affecting cell proliferation and survival that are relevant to normal development and disease. Here we have used a combined approach to study the EGF dependent transcriptome of HeLa cells. We obtained mR...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-17403 | biostudies-arrayexpress
TranscriptomicsLXR activation in RAW264.7 mouse macrophages expressing LXRalpha.
To identify novel LXR target genes, we conducted transcriptional profiling studies using RAW264.7 cells ectopically expressing LXRalpha Total RNA was isolated from RAW264.7 macrophages ectopically expressing LXRalpha as described in Venkateswaran et al. (2000); PNAS 97, 12097-12102. Cells were cult...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-17088 | biostudies-arrayexpress
UnknownMortality and clinical characteristics of multisystem inflammatory syndrome in children (MIS-C) associated with covid-19 in critically ill patients: an observational multicenter study (MISCO study).
Not available
S-EPMC8600488 | biostudies-literature
UnknownRisk factors and outcomes of pediatric non-invasive respiratory support failure in Latin America.
Not available
S-EPMC11997567 | biostudies-literature
UnknownRhinovirus is an important pathogen in upper and lower respiratory tract infections in Mexican children.
Not available
S-EPMC4349319 | biostudies-literature
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