Gorbunova Vera V

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The genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance

Comparative proteome analysis of beaver (Castor canadensis) and mouse (Mus musculus) liver tissues

ORGANISM(S): Castor canadensis Mus musculus (Mouse)

2022-02-16 | PXD028546 | Pride

A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A

Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing two linked substitutions (N308K/A313S) as enriched in Ashkenazi Jewis...

ORGANISM(S): Homo sapiens (Human)

2022-10-21 | PXD035689 | Pride

Lmna Centenarian Longevity Sirt6 Adp-ribosylation Aging

The effect of very-high-molecular-mass hyaluronan (vHMM-HA) on CD44 protein-protein interactions.

Naked mole-rat skin fibroblasts (NSF) produces vHMM-HA. Although NSF-HA has been shown to suppress NSF transformation, it is still unclear if exceptional polymer length of vHMM-HA is important for its functions. Here, we compared the effect of intact control NSF-HA (cNSF-HA) and partially fragmented...

ORGANISM(S): Homo sapiens (Human)

2020-03-24 | PXD013445 | Pride

Naked mole rat / hyaluronan / cd44

Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trial.

Not available

S-EPMC4279237 | biostudies-literature

Randomized phase II study of carboplatin and paclitaxel with either linifanib or placebo for advanced nonsquamous non-small-cell lung cancer.

Not available

S-EPMC5478045 | biostudies-literature

Adjuvant trastuzumab in HER2-positive breast cancer.

Not available

S-EPMC3268553 | biostudies-literature