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ProteomicsMulti-omics Analysis of naive B cells of patients harboring the C104R mutation in TACI
Common variable immunodeficiency (CVID) is the most prevalent form of symptomatic primary immunodeficiency in humans. The genetic cause of CVID is still unknown in about 70% of cases. 10% of CVID patients carry heterozygous mutations in the tumor necrosis factor receptor superfamily member 13B gene ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035459 | Pride
Atac-seq Cd40l stimulation Dna accessibility Proteomics Taci Tnfrsf13b Transcription factor Cvid Naïve b cells Nf-b Rna-seq 
TranscriptomicsTranscription profiling of human EBV transformed cell lines established from patients with a novel immunodeficiency syndrome
Lysosome-related organelles have versatile functions including protein and lipid degradation, signal transduction, and protein secretion. The molecular elucidation of rare congenital diseases affecting endosomal/lysosomal biogenesis has given insights into physiological functions of the innate and a...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6322 | biostudies-arrayexpress
UnknownLRBA regulates actin cytoskeleton dynamics through NMIIA during B cell immune responses
Not available
S-SCDT-10_1038-S44319-026-00831-3 | biostudies-other
TranscriptomicsEngineering Material Properties of Transcription Factor Condensates to Control Gene Expression in HEK-293T Cells
Phase separation of biomolecules into condensates is a key mechanism in the spatiotemporal organization of biochemical processes in cells. We systematically engineered light-inducible transcription factor condensates with different material properties and analyzed their influence on transcription ac...
ORGANISM(S): Homo sapiens 
2024-04-01 | E-MTAB-13905 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neutrophil and PBMC gene expression data from Jobs Syndrome individuals
Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal...
ORGANISM(S): Homo sapiens 
2008-06-17 | E-GEOD-8507 | biostudies-arrayexpress
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