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MetabolomicsUntargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights
UnknownNovel eukaryotes from the permanently anoxic Cariaco Basin (Caribbean Sea).
Not available
S-EPMC194984 | biostudies-literature
TranscriptomicsMurine Embryonic Stems Cells: H3K27me3 in Undifferentiated (UD) and Day 3 (D3) differentiated ES cells
ChIP on chip for H3K27me3 in murine ES cells comparing Undifferentiated and Day 3 differentiated. Paper Abstract: How polycomb group proteins repress gene expression in vivo is not known. Whilst histone modifying activities of the polycomb repressive complexes have been studied extensively, in vitro...
ORGANISM(S): Mus musculus 
2010-05-14 | E-GEOD-20201 | biostudies-arrayexpress
UnknownQualitative interviews of patients with COPD and muscle weakness enrolled in a clinical trial evaluating a new anabolic treatment: patient perspectives of disease experience, trial participation and outcome assessments.
Not available
S-EPMC11031513 | biostudies-literature
UnknownTopical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial.
Not available
S-EPMC4415859 | biostudies-literature
TranscriptomicsmicroRNA expression in bone marrow cells from Gfi1 deficient mice
Growth factor independent-1 (Gfi1) is a zinc finger transcription factor with a SNAG amino-terminal repressor domain and is critically required for normal myelopoesis. Gfi1 is normally expressed in HSCs and induced during differentiation from CMPs to GMPs. Gfi1 loss-of-function mutation in mice and ...
ORGANISM(S): Mus musculus 
2009-03-10 | E-GEOD-15077 | biostudies-arrayexpress
TranscriptomicsRNA-Seq expression data from the reproductive tracts of WT, Hoxa91011, and Hoxd91011 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions, and their interspersed shared enhancers. In this report, we describe a novel recombineering strategy that was used to introduce simultaneous frameshif...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42339 | biostudies-arrayexpress
TranscriptomicsExpression data from the reproductive tracts of WT, Hoxa9,10,11, and Hoxd9,10,11 mutant mice
Hox genes are key regulators of development. In mammals, the study of these genes is greatly confounded by their large number, overlapping functions, and their interspersed shared enhancers. In this report, we describe a novel recombineering strategy that was used to introduce simultaneous frameshif...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-41993 | biostudies-arrayexpress
TranscriptomicsKlf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated membrane Beta1/Beta2-integrin expression
The Kruppel-like factor 5 (Klf5) regulates pluripotent stem cell self-renewal but its role in somatic stem cells is unknown. Klf5 deficient hematopoietic stem cells and progenitors (HSC/P) fail to engraft after transplantation. This HSC/P defect was associated with impaired bone marrow (BM) homing a...
ORGANISM(S): Mus musculus 
2013-01-30 | E-GEOD-43806 | biostudies-arrayexpress
ProteomicsSWATH-MS Analysis of Gfi1-mutant bone marrow neutrophils
This study investigates the proteomic alterations in bone marrow neutrophils isolated from 5-8 week old Gfi1+/-, Gfi1K403R/-, Gfi1R412X/-, and Gfi1R412X/R412X mice using the SWATH-MS technique. This dataset consists of 26 raw MS files, comprising 13 DDA (for spectral library generation)and 13 DIA (f...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-07 | PXD010943 | Pride
Scn Gfi1 Swath Neutrophil 
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