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UnknownPrognostic roles of KL-6 in disease severity and lung injury in COVID-19 patients: A longitudinal retrospective analysis.
Not available
S-EPMC8013517 | biostudies-literature
TranscriptomicsIdentification of differential expressed genes between P-RPCs, ESC-RPCs and Dkk1 treated ESC-RPCs through genome-wide transcript profiling
Tumor formation constitutes a major obstacle to the clinical application of embryonic stem cells (ESCs). As P-RPCs could successfully integrate into host eyes without development of teratomas or NOG, we sought to identify differentially expressed genes between P-RPCs and ESC-RPCs through genome-wide...
ORGANISM(S): Mus musculus 
2013-04-16 | E-GEOD-34002 | biostudies-arrayexpress
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
ProteomicsmTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT
Mutations in cancer reprogram amino acid metabolism to drive tumor growth, but the molecular mechanisms are not well understood. Using an unbiased proteomic screen, we identified mTORC2 as a critical regulator of amino acid metabolism in cancer via phosphorylation of the cystine-glutamate antiporter...
ORGANISM(S): Homo sapiens (Human) 
2017-06-28 | PXD006461 | Pride
Mtorc2 Xct 
TranscriptomicsPDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
Although 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to PI3K-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces Myc ...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
TranscriptomicsInhibition of astroglial NF-kB regulates oligogenesis following spinal cord injury.
Astrocytes are taking the center stage in neurotrauma and neurological disease as they appear to play a dominant role in the inflammatory processes associated with these conditions. Previously, we reported that inhibiting nuclear factor kappa B (NF-kB) activation in astrocytes, by using a transgenic...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-46695 | biostudies-arrayexpress
TranscriptomicsWhite Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans
Modes of sexual reproduction in eukaryotic organisms are highly diversified. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally and morphologically differentiated ...
ORGANISM(S): Candida albicans 
2014-10-23 | E-GEOD-56039 | biostudies-arrayexpress
TranscriptomicsRNA_seq_Salmonella_pig
Salmonella enterica serovar Typhimurium is a gram-negative bacterium that can colonize the gut of humans and several species of food producing farm animals to cause enteric or septicaemic salmonellosis. Besides compromising public health and food safety, sub-clinical salmonellosis is also believed t...
ORGANISM(S): Sus scrofa 
2014-06-11 | E-MTAB-2234 | biostudies-arrayexpress
UnknownKlotho Protects Against Indoxyl Sulphate-Induced Myocardial Hypertrophy.
Not available
S-EPMC4587686 | biostudies-literature
TranscriptomicsYAP mediates crosstalk between the Hippo and PI3K-TOR pathway by suppressing PTEN via miR-29
We aimed to identify microRNAs that are regulated by YAP in human mammary epithelial cells. We utilized deep sequencing technology to identify microRNAs that are induced by YAP overexpression and repressed by YAP knockdown.
ORGANISM(S): Homo sapiens 
2012-10-01 | E-GEOD-41124 | biostudies-arrayexpress
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