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The SLC25A26 gene encodes a mitochondrial inner membrane carrier that transports S-adenosylmethionine (SAM) into the mitochondrial matrix in exchange for S-adenosylhomocysteine (SAH). SAM is the predominant methyl-group donor for most cellular methylation processes, of which SAH is produced as a by-...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-01-19 | PXD026900 | Pride
Lung cancer is the leading cause of cancer death both in men and women. Tumor heterogeneity is an impediment to targeted treatment of all cancers, including lung cancer. Here, we sought to characterize changes in tumor proteome and phosphoproteome by longitudinal, prospective collection of tumor tis...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010779 | Pride
Lung cancer is the leading cause of cancer death. Mutations in the kinase domain of EGFR, a predominant driver oncogene, such as L858R missense mutation and a series of deletions spanning the conserved sequence 747LREA750, are associated with sensitivity to tyrosine kinase inhibitors (TKIs). However...
ORGANISM(S): Homo sapiens (Human) 
2017-03-29 | PXD004373 | Pride
Cell lines representing five distinct phenotypes of high-grade serous ovarian carcinoma (HGSOC), including Epithelial (E), Intermediate-Epithelial (iE), Epithelial-Mesenchymal Hybrid (E/M), Intermediate-Mesenchymal (iM), and Mesenchymal (M), previously classified in our laboratory based on the expre...
ORGANISM(S): Homo sapiens (Human) 
2025-10-08 | PXD062888 | Pride
Intratumor mutational heterogeneity has been documented in primary non-small cell lung cancer. Here, we elucidate mechanisms of tumor evolution and heterogeneity in metastatic thoracic tumors (lung adenocarcinoma and thymic carcinoma) using whole-exome and transcriptome sequencing, SNP array for cop...
ORGANISM(S): Homo sapiens (Human) 
2019-05-07 | PXD012845 | Pride
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