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MetabolomicsCell Membrane Remodeling Mediates Polymyxin B Resistance in Klebsiella pneumoniae: An Integrated Proteomics and Metabolomics Study
Polymyxin B (PB) is introduced into the clinic as the last-line therapy against carbapenem-resistant Klebsiella pneumoniae (CRKP). Unfortunately, increased resistance to PB in Klebsiella pneumoniae (K. pneumoniae) has threatened global health. Resistance of K. pneumoniae ...
2022-03-04 | MTBLS4132 | MetaboLights
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
ProteomicsProteomic analysis of E. coli K-12 LE392, P. putida KT2440 under exposure of carbamazepine
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of wild-type E. coli K-12 LE392, P. putida KT2440, and their quantitative protein response under the exposure of antiepileptic drug carbamazepine. Three concentrations of carbamazepine were applied, which were 0.05 mg...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2018-10-10 | PXD009279 | Pride
Carbamazepine Swath-ms P. putida E. coli 
ProteomicsIdentification of vitamin K-dependent proteins in mouse liver by LC-MS/MS
Vitamin K (VK), a fat-soluble vitamin, functions as a co-factor during the gamma-carboxylation reaction that converts glutamic acid residues to gamma-carboxyglutamic acid residues in proteins transiting through the endoplasmic reticulum. Two enzymes are involved which together form the VK cycle: gam...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032920 | Pride
Gamma-carboxylation Mouse Liver Vitamin k Lc-ms/ms 
ProteomicsProteomic analysis of E. coli K-12 LE392, P. putida KT2440 under exposure of six non-antibiotic pharmaceuticals
The goals of this study are to use SWATH-MS to detect bacterial proteomic profiles of E. coli K-12 LE392 with conjugative RP4 plasmid, P. putida KT2440, and their protein response under the exposure of six kinds of non-antibiotic pharmaceuticals, i.e., ibuprofen (ibu), naproxen (nap), gemfibrozil (g...
ORGANISM(S): Escherichia coli Pseudomonas putida KT2440 
2022-02-15 | PXD012642 | Pride
Non-antibiotic pharmaceuticals Swath-ms P. putida E. coli 
ProteomicsiTRAQ-based proteomic analysis reveals genome-wide protein expression patterns in allohexaploid bread wheat in adaptation to potassium deficiency and an important role of jasmonic acid
Two-week old bread wheat seedlings hydroponically grown Hoagland solution were transferred to potassium (K+)-free conditions for 8 d, their root and leaf proteome profiles were assessed using iTRAQ proteome method, and NCBInr database combined with the recently published bread wheat genome informati...
ORGANISM(S): Triticum aestivum (Wheat) 
2017-10-09 | PXD003570 | Pride
Jasmonic acid Triticum aestivum l. Itraq Potassium deficiency 
UnknownGuanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors.
Not available
S-EPMC9560947 | biostudies-literature
ProteomicsIntegrative proteomic and transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1
Lo A, Holmes K, Mundt F, Moorthi S, Fung I, Fereshetian S, Watson J, Carr SA, Mertins P, Berger A. Aberrant activation of RAS oncogenes is a prevalent event in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. Recently, we identified somatic mutation of the RAS-family G...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-03 | MSV000085225 | MassIVE
UnknownKUP9 maintains root meristem activity by regulating K+ and auxin homeostasis in response to low K
Not available
S-SCDT-EMBOR-2020-50164-T | biostudies-other
UnknownKUP9 maintains root meristem activity by regulating K+ and auxin homeostasis in response to low K.
Not available
S-EPMC7271654 | biostudies-literature
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