Sort   by:  
 Page size 
GenomicsDual Binding of Chromomethylase Domains to H3K9me2-containing Nucleosomes Mediates DNA Methylation in PlantsM-BM-
DNA methylation and histone modification exert epigenetic control over gene expression. CHG methylation by CHROMOMETHYLASE3 (CMT3) depends on histone H3K9 dimethylation (H3K9me2), but the mechanism underlying this relationship is poorly understood. Here, we report multiple lines of evidence that CMT...
ORGANISM(S): Arabidopsis thaliana 
2012-11-11 | E-GEOD-39097 | biostudies-arrayexpress
GenomicsG9a/GLP-dependent H3K9me2 patterning alters chromatin structure at CpG islands in hematopoietic progenitors.
We profiled chromatin accessibility across the genome of HSPCs treated with either a small molecule inhibitor of G9a/GLP or DMSO. We observed that chromatin accessibility is dramatically altered at the regions of H3K9me2 nucleation. We have characterized the regions of H3K9me2 nucleation, revealing ...
ORGANISM(S): Homo sapiens 
2014-09-25 | E-GEOD-59749 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of H3K9me2 in Arabidopsis thaliana
The objective of the study is to profile histone H3 lysine nine di-methylation (H3K9me2) in Arabidopsis thaliana and to correlate it with DNA methylation. We constructed a high-resolution genome-wide map of H3K9me2 methylation by using native chromatin immunoprecipitation coupled with HD2 whole geno...
ORGANISM(S): Arabidopsis thaliana 
2010-06-19 | E-GEOD-12383 | biostudies-arrayexpress
TranscriptomicsThe SET-domain protein SUVR5 mediates H3K9me2 deposition and silencing at stimulus response genes in a DNA methylation independent manner [ChIP-chip]
In eukaryotic cells, environmental and developmental signals alter chromatin structure and modulate gene expression. Heterochromatin constitutes the transcriptionally inactive state of the genome and in plants and mammals is generally characterized by DNA methylation and histone modifications such a...
ORGANISM(S): Arabidopsis thaliana 
2014-06-06 | E-GEOD-58030 | biostudies-arrayexpress
TranscriptomicsChIP-seq of histone H3 and H3K9me2 in WT and dbl2 mutant fission yeast
The aim was to compare the levels of histone H3 dimethylation at lysine 9 (H3K9me2) in wild-type and dbl2 knock-out Schizosaccharomyces pombe cells. Fission yeast cultures were grown in the complex YES medium to exponential phase and chromatin immunoprecipitation was carried out using anti-H3 and an...
ORGANISM(S): Schizosaccharomyces pombe 
2020-10-02 | E-MTAB-9619 | biostudies-arrayexpress
TranscriptomicsEnrichment of H3K9me2 on unsynapsed chromatin in C. elegans does not target de novo sites [RNA-Seq]
We sequenced mRNA isolated from adult hermaphrodite met-2;him-8 and him-8 gonads in order to determine the gene expression profile of germ cells with or without H3K9me2. Examination of mRNA profiles in nematode gonad of met-2;him-8 (without H3K9me2) and him-8 (with H3K9me2)
ORGANISM(S): Caenorhabditis elegans 
2015-09-04 | E-GEOD-67029 | biostudies-arrayexpress
TranscriptomicsChip-chip from human ES cells (H1), iPS cells (iPSC38), astrocytes (HA) and aortic endothelial cells (HAEC) with H3K9me2 antibody
Histone modification H3K9me2 is associated with gene silencing and forming large heterochromatin domains. But the micro-structure within large H3K9me2 domains and their relationship with DNA methylation remains unclear. This dataset was generated to compare with genome-wide DNA methylation data. Gen...
ORGANISM(S): Homo sapiens 
2013-02-17 | E-GEOD-37335 | biostudies-arrayexpress
GenomicsEnrichment of H3K9me2 on unsynapsed chromatin in C. elegans does not target de novo sites [ChIP-Seq]
Characterization of the H3K9me2 distribution in the C. elegans adult hermaphrodite genome using ChIP-Seq Examination of H3K9me2 in two different nematode strains: fer-1 control and fer-1;him-8 mutant, where the X chromosomes are unsynapsed. The fer-1 mutation prevents production of embryos.
ORGANISM(S): Caenorhabditis elegans 
2015-09-04 | E-GEOD-67028 | biostudies-arrayexpress
ProteomicsMBD8 is required for LDL2-mediated transcriptional repression downstream of H3K9me2 in Arabidopsis
Histone H3 lysine 9 methylation (H3K9me) is a conserved epigenetic mark for transcriptional gene repression. In Arabidopsis, H3K9 dimethylation (H3K9me2) promotes the removal of a transcription-associated mark, H3K4 monomethylation (H3K4me1), and this process within genes requires the histone demeth...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-08 | PXD069014 | Pride
Arabidopsis Ldl2 Mbd8 
GenomicsEpigenetic Repogramming by an Environmental Carcinogen Through Chromatin Domain Disruption [ChIP-Seq]
Alterations in chromatin modifications, including DNA methylation and histone modification patterns, have been characterized under exposure of several environmental pollutants, including nickel. As with other carcinogenic metals, the mutagenic potential of nickel compounds is low and is not well cor...
ORGANISM(S): Homo sapiens 
2014-09-26 | E-GEOD-56051 | biostudies-arrayexpress
Sort   by:  
 Page size