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TranscriptomicsTranscriptome analysis of Bacillus subtilis salt stress adaptation
Whole-genome microarray technology and state-of-the-art proteomic techniques were applied to provide a global and time-resolved picture of the physiological response of B. subtilis cells exposed to a severe and sudden osmotic up-shift. This combined experimental approach provided quantitative data f...
ORGANISM(S): Bacillus subtilis 
2010-05-19 | E-GEOD-18345 | biostudies-arrayexpress
ProteomicsDecrypting drug actions and protein modifications by dose- and time-resolved chemical proteomics
Measuring dose-dependent effects of drugs on post-translational modifications on a proteome-wide scale reveals how these drugs work in cells. Here, we present a quantitative chemical proteomic approach termed decryptM, able to assess target and pathway engagement as well as the mode of action (MoA)...
ORGANISM(S): Homo sapiens (Human) 
2023-03-17 | PXD037285 | Pride
Kat Screen Drug mode of action Post-translational modifciation Time-resolved Inhibitors Decryptm Proteome-wide Hdac Dose-resolved Kinase 
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
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