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TranscriptomicsRNAseq of organ-cultured human hair follicles exposed to MEKi (Cobimetinib)
EGFR/MEK inhibitor therapy induces a distinct inflammatory hair follicle response that includes a collapse of hair follicle immune privilege and differential modulation of IL-33 and IL-37 expression. Our findings suggest that successful future management of EGFRi/MEKi-induced folliculitis requires r...
ORGANISM(S): Homo sapiens 
2024-07-19 | E-MTAB-13454 | biostudies-arrayexpress
GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
TranscriptomicsLgr6 Marks Stem Cells in the Hair Follicle that Generate all Cell Lineages of the Skin
Mammalian epidermis consists of three self-renewing compartments: the hair follicle, sebaceous gland and interfollicular epidermis. We generated knock-in alleles of murine Lgr6, a close relative to the Lgr5 stem cell gene. Lgr6 was expressed in the earliest embryonic hair placodes. In adult hair fol...
ORGANISM(S): Mus musculus 
2010-03-25 | E-GEOD-20269 | biostudies-arrayexpress
TranscriptomicsExpression profiling of Bmal mutant dorsal skin at telogen of hair follicle cycling
Hair follicles undergo recurrent cycling of controlled growth (anagen), regression (catagen), and relative quiescence (telogen) with a defined periodicity. Taking a genomics approach to study gene expression during synchronized mouse hair follicle cycling, we discovered that, in addition to circadia...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-14006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hair follicles from men and women
Investigation of Gene Expression Profiling in Unstaged Head Hair Follicles Plucked from Men and Women Experiment Overall Design: Total RNA was extracted from 1-3 unstaged follicles plucked from the scalp of each of 36 adult human volunteers. The average quantifiable yield of RNA per follicle was 11...
ORGANISM(S): Homo sapiens 
2007-12-11 | E-GEOD-3058 | biostudies-arrayexpress
MetabolomicsACOD1 deficiency promotes dermal papilla cell senescence via mitochondrial dysfunction in androgenetic alopecia

Background Androgenetic alopecia (AGA), the most prevalent form of hair loss, is driven by the dysfunction of dermal papilla cells (DPCs). Emerging evidence implicates DPC senescence in the pathogenesis of AGA; however, the underlying molecular mechanisms remain incompletely elucidated.

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2026-05-23 | MTBLS14024 | MetaboLights
ProteomicsReprocessed: Chick utricle hair bundles and utricular epithelium—Orbitrap
This is a reanalysis of PXD000104. Purified hair bundles and utricular epithelium from E19-E20 chick inner ears were analyzed by LC-MS/MS to determine the abundant and enriched proteins of the hair bundle. This dataset used a Thermo Orbitrap Elite mass spectrometer for protein detection.
ORGANISM(S): Gallus gallus (Chicken) 
2015-11-17 | PXD002445 | Pride
Vestibular Hair cells Stereocilia Utricle 
TranscriptomicsTranscription profiling of mouse hair follicle stem cell
Mouse keratinocytes were isolated from K15-EGFP transgenic mice for FACS sorting. RNA samples from EGFP-high and alpha-6 integrin positive cells (hair follicle stem cells) and from EGFP negative and alpha-6 integrin positive cells were used for Microarray analysis.
ORGANISM(S): Mus musculus 
2007-10-06 | E-GEOD-1096 | biostudies-arrayexpress
ProteomicsMouse wild-type and Anxa5-null utricles and hair bundles
The phospholipid- and Ca2+-binding protein annexin A5 (ANXA5) is the most abundant membrane-associated protein of ~P23 mouse vestibular hair bundles, present at ~15,000 copies per stereocilium, which is ~2% of the total protein there. Although seven other annexin genes are expressed in mouse utricle...
ORGANISM(S): Mus musculus (Mouse) 
2016-06-09 | PXD003005 | Pride
Hair cells Annexins Vestibular Stereocilia 
TranscriptomicsEffects of a Closed Space Environment on Gene Expression in Hair Follicles of Astronauts in the International Space Station
In recent times, long-term stay has become a common occurrence in the International Space Station (ISS). However, adaptation to the space environment can sometimes pose physiological problems to the astronauts after their return. Therefore, it is important to develop healthcare technologies for astr...
ORGANISM(S): Homo sapiens 
2016-03-31 | E-GEOD-74708 | biostudies-arrayexpress
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