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ProteomicsThe gut microbiota affects the mucus barrier
Two C57BL/6 mice colonies maintained in two rooms in the same specific pathogen free (SPF) facility were found to have different gut microbiota and a mucus phenotype specific for each colony. The thickness and growth of the colon mucus was similar in the two colonies, but one colony had mucus not pe...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-09 | PXD001479 | Pride
Microbiota Mucus Colon Ileum 
ProteomicsDefective ribosome assembly impairs leukemia progression in a murine model of acute myeloid leukemia
Despite the advanced understanding of disease mechanisms, the current therapeutic regimens fail to cure most patients with acute myeloid leukemia (AML). In the present study, we address the role of protein synthesis control in AML leukemia stem cell (LSC) function and leukemia propagation. We apply ...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-08 | PXD038318 | Pride
Aml Ribosome Lsc 
TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
ProteomicsSTRUCTURAL WEAKENING OF THE COLONIC MUCUS BARRIER IS AN EARLY EVENT IN ULCERATIVE COLITIS PATHOGENESIS
The colonic inner mucus layer protects us from pathogen invasion and commensal-induced inflammation. Mucus abnormalities are common in ulcerative colitis (UC), but their cause and importance are unknown. The aim of this study was to determine the role of compositional mucus barrier alterations in UC...
ORGANISM(S): Homo sapiens (Human) 
2021-03-26 | PXD012632 | Pride
Lc-ms/ms and ibd Human Mucus Ileum Colon 
UnknownMagnetic resonance imaging incidents are severely underreported: a finding in a multicentre interview survey.
Not available
S-EPMC8660737 | biostudies-literature
ProteomicsQuantitative proteome analysis to map the targets of small molecule UM171
Earlier we identified the protein degradation properties of small molecule UM171 (Subramaniam et al., 2020, Blood). Here we employed quantitative proteomics approach to map the global targets of UM171. Our study revealed multiple targets including the members of CoREST complex such as RCOR1 and LSD1...
ORGANISM(S): Homo sapiens (Human) 
2023-03-30 | PXD037999 | Pride
Um171 Protein degradation. Corest 
UnknownWolbachia-driven selective sweep in a range expanding insect species.
Not available
S-EPMC8466699 | biostudies-literature
UnknownAntisecretory Factor May Reduce ICP in Severe TBI-A Case Series.
Not available
S-EPMC7067821 | biostudies-literature
ProteomicsQuantitative extracellular proteome analysis of fetal liver and adult bone marrow
We describe the proteomic composition of the extracellular environment of fetal and adult hematopoietic progenitors by data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Mus musculus (Mouse) 
2024-04-02 | PXD042251 | Pride
Tissue interstitial fluid Bone marrow Fetal liver Data-independent acquisition Extracellular 
ProteomicsSecretome and phosphoproteome analysis of THP-1 and KOPN-8 cells treated with Insulin-like growth factor 2.
We describe the secretome and phosphoproteome of human leukemia cell lines, THP-1 and KOPN-8, treated with Insulin-like growth factor 2 (IGF2) using data-independent acquisition mass spectrometry analysis.
ORGANISM(S): Homo sapiens (Human) 
2024-04-02 | PXD049016 | Pride
Leukemia Secretome Extracellular Data-independent acquisition Phosphoproteome Igf2 
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