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MetabolomicsImaginal disc growth factor maintains cuticle structure and controls melanization in the spot pattern formation of Bombyx mori

The complex stripes and patterns of insects play key roles in behavior and ecology. However, the fine-scale regulation mechanisms underlying pigment formation and morphological divergence remain largely unelucidated. Here we demonstrated that imaginal disc growth factor (IDGF) maintains cuticle s...

2020-09-20 | MTBLS1825 | MetaboLights
UnknownFABP5 in skin macrophages mediates saturated fat-induced IL-1β signaling in psoriatic inflammation.
Not available
S-EPMC12516882 | biostudies-literature
ProteomicsLabel-Free Absolute Protein Quantification with Data-Independent Acquisition
Label-free absolute quantitative proteomics is commonly used for absolute quantification of the proteome or specific proteins of interest in various biological samples. Current label-free absolute protein quantification (APQ) methods determine MS1 intensities, MS2 spectral counts or intensities to a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD010912 | Pride
Human Dia S9 Absolute protein quantification Microsome Liver Dda 
ProteomicsGenome-wide pQTL analysis of protein expression regulatory networks in the human liver
Background: Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein quantitative trait loci...
ORGANISM(S): Homo sapiens (Human) 
2020-07-21 | PXD019169 | Pride
Liver Hls9 Dia 
UnknownKeratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis.
Not available
S-EPMC10729729 | biostudies-literature
UnknownDevelopment of a humanized anti-FABP4 monoclonal antibody for potential treatment of breast cancer.
Not available
S-EPMC11270797 | biostudies-literature
ProteomicsBCL7A’s Arginine Anchor Links Nucleosome Recognition to Chromatin Remodeling and DLBCL Tumor Suppression
The N-terminal α-helix of BCL7A, a non-catalytic subunit, exhibits characteristic positive charge distribution. To delineate its contribution to chromatin remodeling and gene regulation, we engineered an N-terminal deletion and performed functional comparisons with wild-type BCL7A in chromatin remod...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD064944 | Pride
Cbaf Human swi/snf Chromatin remodeling complex Bcl7a 
ProteomicsProteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor ant...
ORGANISM(S): Mus Musculus 
2024-07-05 | PXD053688 |
ProteomicsRegulation of Cortical Neurogenesis by MED13L via Transcriptional Priming and its Implications for MED13L Syndrome
MED13L is highly susceptible to neurodevelopmental disorders, yet the underlying developmental mechanisms remain poorly understood. We developed a gene knockout mouse model of MED13L syndrome to elucidate these mechanisms. Homozygous Med13l-null mice exhibit neonatal lethality and severe cortical ne...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-09 | PXD055474 | Pride
Mediator complex Neural progenitors Med13l syndrome Neurogenesis Cerebral cortex 
ProteomicsCCL20/CXCL5 regulates the stemness of anaplastic thyroid cancer stem cells via NF-kB pathway
The mechanism of CCL20/CXCL5 regulating anaplastic thyroid cancer cancer stem cells to promote the progression of thyroid cancer
ORGANISM(S): Homo Sapiens 
2023-11-13 | PXD046889 |
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