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ProteomicsPhosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress
The DNA damage response (DDR) is a complex signaling network that relies on cascades of protein phosphorylation, which are initiated by three protein kinases of the family of PI3-kinase-related protein kinases (PIKKs): ATM, ATR and DNA-PK. ATM is missing or inactivated in the genome instability syn...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD020884 | Pride
Atr Ddr Atm Dna-pk Dna damage 
ProteomicsPhosphoproteomics reveals novel modes of function and inter-relationships among PIKKs in response to genotoxic stress
The DNA damage response (DDR) is a complex signaling network that is robustly mobilized by double-strand breaks (DSBs) in the DNA. This network relies on extensive cascades of protein phosphorylation and dephosphorylation, which are initiated by three apical protein kinases that belong to the family...
ORGANISM(S): Homo sapiens (Human) 
2020-11-25 | PXD015455 | Pride
Human Atr Atm Dna-pk Ddr Lc-ms/ms 
ProteomicsThe mammalian longevity associated acetylome
Despite extensive studies at the genomic, transcriptomic and metabolomic levels, the underlying mechanisms regulating longevity are incompletely understood. Post-translational protein acetylation is suggested to regulate aspects of longevity. To further explore the role of acetylation, we develop th...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-30 | PXD061654 | Pride
Acetylome Longevity Pharaoh 
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