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ProteomicsExtracellular Matrix Protein 1 as a critical mediator of inflammation-to-fibrosis crosstalk in wound healing after myocardial infarction
Aims and introduction: Cardiac fibrosis is the hallmark of cardiac disease, particularly myocardial infarction (MI), and is one of the most prevalent causes of heart failure. MI is intricately linked to inflammation, extracellular matrix (ECM) remodelling, and cardiac fibrosis, however the mechanism...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD027626 | Pride
Ecm1 Adult human cardiac fibroblast (hucfb) cell line Human Cardiac wound healing Extracellular matrix Heart failure (hf) 
TranscriptomicsIdentification of genes critical for resistance to infection by West Nile virus using RNA-Seq analysis
Background: West Nile virus is an emerging infection of biodefense concern and there are no available treatments or vaccines. Here we used a high-throughput method based on a novel gene expression analysis, RNA-Seq, to give a global picture of differential gene expression by primary human macrophage...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-40718 | biostudies-arrayexpress
UnknownQuantifying the extent to which index event biases influence large genetic association studies.
Not available
S-EPMC5661557 | biostudies-literature
Transcriptomicsprofiling of an organ-specific sunflower transcriptoma under abiotic stress (salinity and cold conditions)
Sunflower is an important source of vegetable oil worlwide. A differential organ-specific sunflower ESTs was previously generated by a subtractive hybridization method, including a considerable number of abiotic stress associated sequences. The objective of this work is to analyze the sunflower gene...
ORGANISM(S): Helianthus annuus 
2010-06-30 | E-GEOD-6201 | biostudies-arrayexpress
TranscriptomicsDifferential in vivo tumorigenicity of distinct subpopulations from a luminal-like breast cancer model (SNP)
The cellular heterogeneity of one patient derived orthotopic breast cancer xenograft model PDX was investigated using flow cytometry, combined with assessment of in vivo tumorigenicity and SNP genotyping array for copy number analysis. Epithelial cell adhesion molecule (EpCAM) was revealed as a high...
ORGANISM(S): Homo sapiens 
2015-05-26 | E-GEOD-54595 | biostudies-arrayexpress
TranscriptomicsCharacterization of pathogen specific expression of host immune response genes in Mycobacterium and Anaplasma spp. infection in ruminants
Anaplasma and Mycobacterium species are known to modify gene expression in ruminants. The objectives of this study were (a) to characterize global gene expression profiles in European red deer (Cervus elaphus) in response to Anaplasma ovis and A. ovis/Mycobacterium bovis/M. avium sub. paratuberculos...
ORGANISM(S): Cervus elaphus 
2010-12-31 | E-GEOD-21967 | biostudies-arrayexpress
TranscriptomicsPlacental gene expression in severe preeclampsia.
The series is composed of thirty hybridizations for analysis of differentially expressed genes in normal placenta tissues from patients with normal labor and placenta tissues from patients with severe preeclampsia. Patients tissues samples were obtained from (Vasilis. Total RNA extraction was perfor...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10588 | biostudies-arrayexpress
TranscriptomicsGene expression profiling indicates inflammatory pathways involved in IUGR due to placental insufficiency
Intrauterine growth restriction (IUGR) represents a major obstetric challenge with perinatal complications and a risk factor of developing disease in adult life. Placental insufficiency is one of the common features accompanying IUGR. The aim of this study was to evaluate global placental gene ...
ORGANISM(S): Homo sapiens 
2008-08-01 | E-GEOD-12216 | biostudies-arrayexpress
MetabolomicsHost autophagy mediates organ wasting and nutrient mobilization for tumor growth
During tumor growth-when nutrient and anabolic demands are high-autophagy supports tumor metabolism and growth through lysosomal organelle turnover and nutrient recycling. Ras-driven tumors additionally invoke non-autonomous autophagy in the microenvironment to support tumor growth, in part through ...
2021-09-24 | MTBLS2771 | MetaboLights
UnknownFLT3L-secreting cDC1 in situ vaccination enhances antitumor immunity and synergizes with PD-1 blockade in murine non-small cell lung cancer.
Not available
S-EPMC13311619 | biostudies-literature
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