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ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
ProteomicsTowards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics
Objective: Head and neck cancer (HNC) accounts for almost 850,000 new cases per year. Radiotherapy (RT) is used to treat the majority of these patients. A common side-effect of RT-treatment is onset of oral mucositis: a painful irritation and swelling in mouth, which decreases the quality of life an...
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD040398 | Pride
Keratinocytes Interferon response Stat phosphorylation Radiotherapy Mass spectrometry-based proteomics Biomarker Mcm complex 
ProteomicsAltered porcine PBMC proteome and secretome after stimulation with BanLec
With this experiment, we aimed at showing changes in the proteome and secretome of porcine peripheral blood mononuclear cells (PBMC) after stimulation with Banana Lectin (BanLec).
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-08-26 | PXD027505 | Pride
Pbmc Musa banana Polyclonal cell stimulation Banlec Plant lectin Pig Lc-ms/ms 
ProteomicsBiomarkers of favorable immune capacity in growth hormone receptor knockout pig model
Laron Syndrome (LS) is a rare hereditary disease in humans caused by a mutation in the growth hormone receptor gene which leads to high levels of circulating GH [1]. The disease is characterized by short statue, obesity, transient hypoglycemia during youth and low incidences of cancer and diabetes [...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-20 | PXD038772 | Pride
Quantitative label-free lc-ms/ms  laron syndrome  ghr-ko  porcine model  immune function 
ProteomicsThe proteomic landscape of patient-derived CD4+ T cells in recent-onset type 1 diabetes
The pathophysiology underlying the autoimmune disease type 1 diabetes (T1D) is poorly understood. Obtaining an accurate proteomic profile of the T helper cell population is essential for understanding the pathogenesis of T1D. Here, we performed in-depth proteomic profiling of peripheral CD4+ T cells...
ORGANISM(S): Homo sapiens (Human) 
2017-11-30 | PXD007184 | Pride
Data-independent Inflammation Neutrophil Cd4+ t cells Type 1 diabetes Biomarker Autoimmune Lc-ms/ms 
ProteomicsThe proteome of native adult Müller cells from the murine retina
We set out to first establish and validate a novel rapid method of enriching adult Müller cells, which yields sufficient cell numbers for proteomic profiling while keeping cells viable and morphologically, as well as physiologically fully intact. From these preparations we collected a comprehensive ...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-15 | PXD002247 | Pride
Lc-msms Macs Retina Fasp Muller glia cell 
ProteomicsProteome changes in retinal Mueller glial cells from a spontaneous equine model for autoimmune uveitis compared to healthy controls
Retinal Müller glial cells (RMG) play a central role in retinal neuroinflammation, actively participating in the immune response and adopting a dynamic inflammatory phenotype. However, the precise functions of RMG in retinal inflammation remain incompletely understood. In this study, we investigated...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD058170 | Pride
Quantitative label-free lc-ms/ms  retinal neuroinflammation  autoimmune uveitis  equine recurrent uveitis (eru)  spontaneous equine animal model  retinal mueller glial cells (rmg) 
ProteomicsThe porcine granulocyte proteome: expression changes in a transgenic pig model for diabetes
As transgenic INSC94Y-pigs develop a stable diabetic phenotype we were able to study the influence of elevated blood glucose levels on primary immune cells in vivo. We investigated the neutrophil proteome and compared data of transgenic animals to a control group. A total of 2371 proteins describing...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2020-06-04 | PXD017274 | Pride
Differential proteomics Innate immune cell Neutrophil granulocyte Diabetes 
ProteomicsLC-MSMS on mouse retina to investigate photoreceptor degeneration
Intraocular anti-VEGFA injections are frequently used to counteract neovascularization in diseases such as the neovascular (wet) form of age-related macular degeneration (AMD) or proliferative diabetic retinopathy. However, in the clinical context, patients with atrophic (dry) and wet AMD in the sam...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-15 | PXD066263 | Pride
Vegfr2 deletion Photoreceptor Lc-msms 
ProteomicsTcell surface analysis - A combined omics approach to generate the surface atlas of human naive CD4+ T cells during early TCR activation
Naive CD4+ T cells are the common precursors of multiple effector and memory T cell subsets and possess a high plasticity in terms of differentiation potential. This stem-cell like character is important for cell therapies aiming at regeneration of specific immunity. Cell surface proteins are crucia...
ORGANISM(S): Homo sapiens (Human) 
2015-05-27 | PXD001432 | Pride
T-cells 
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