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ProteomicsNeuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina
Chronic ocular inflammation is associated with many retinal degenerative diseases that result in vision loss. The immune-privileged environment and complex organization of retinal tissue allow for the retina’s essential role in visual function processes, yet confound inquiries into cell-specific inf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016872 | Pride
Caveolin-1  caveolin  caveolae  inflammation  neural retina  retina  retinal degeneration  immune response 
ProteomicsThe injury environment critically influences the brain-wide input connectome of transplanted neurons
Cell transplantation is a promising approach for reconstruction of neuronal circuits after brain damage. Transplanted neurons integrate with remarkable specificity into circuitries of the mouse cerebral cortex affected by neuronal ablation. However, it remains unclear how neurons perform in a local ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023660 | Pride
Neuronal replacement Circuit mapping Cell therapy Inflammation Transplantation Synaptic yield Injury proteome 
ProteomicsExcessive local host-graft connectivity in aged and amyloid-loaded brain
Transplantation is a clinically relevant approach for brain repair, but much remains to be understood about influences of the disease environment in the host on transplant connectivity. To explore the influence of ageing and amyloid pathology in Alzheimer's disease (AD) we examined graft connectivit...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023407 | Pride
Synaptic connectivity Mouse brain Alzheimer's disease model Aging 
ProteomicsHuman TRMT2A methylates different components of the translation machinery and contributes to translation fidelity
Methyl-5-uridine (m5U) is one of the most abundant RNA modifications found in cytosolic tRNA. tRNA methyltransferase 2 homolog A (hTRMT2A) is the dedicated mammalian enzyme of m5U conversion at tRNA position 54. However, its RNA binding specificity and functional role in the cell are not well unders...
ORGANISM(S): Homo sapiens (Human) 
2023-07-04 | PXD036538 | Pride
Rna biogenesis Translational fidelity Methyl-5-uridine (m5u) Rna methylation Trna methyltransferase 2 homolog a (htrmt2a) Interactome Mammalia 
ProteomicsProteomic phenotyping of stimulated Müller cells uncovers profound pro-inflammatory signaling and antigen-presenting capacity
Müller cells are the main macroglial cells of the retina exerting a wealth of functions to maintain retinal homoeostasis. Upon pathological changes in the retina, they become gliotic with both protective and detrimental consequences. Accumulating data also provide evidence for a pivotal role of Müll...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-02-16 | PXD028390 | Pride
Pro-inflammatory Complement system Cytokines. retina Immune response Müller cells Atypical antigen-presenting cell Diabetic retinopathy 
ProteomicsTowards unravelling biological mechanisms behind radiation-induced oral mucositis via mass spectrometry-based proteomics
Objective: Head and neck cancer (HNC) accounts for almost 850,000 new cases per year. Radiotherapy (RT) is used to treat the majority of these patients. A common side-effect of RT-treatment is onset of oral mucositis: a painful irritation and swelling in mouth, which decreases the quality of life an...
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD040398 | Pride
Keratinocytes Interferon response Stat phosphorylation Radiotherapy Mass spectrometry-based proteomics Biomarker Mcm complex 
ProteomicsPantothenate kinase 4 controls skeletal muscle substrate metabolism
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote efficient energy metab...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-25 | PXD057017 | Pride
Pantothenate kinase 4 (pank4) Lipid and glucose metabolism Skeletal muscle 
ProteomicsChanges in Mycobacterium avium subsp. paratuberculosis proteome after cultivation in milk
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease in cattle. MAP can be either shed directly into milk by infected cows, or introduced via fecal contamination. Viable MAP are detectable in milk and other dairy products, indicating survival of MAP after t...
ORGANISM(S): Bos taurus (Bovine) Mycobacterium avium subsp. paratuberculosis 
2021-08-26 | PXD027444 | Pride
Mycobacterium avium subspecies paratuberculosis Dairy product Milk Food safety Lc-ms/ms 
ProteomicsMycobacterium avium subsp. paratuberculosis infected cows reveal divergent immune response in bovine peripheral blood derived lymphocyte proteome
Bovine paratuberculosis is a serious chronic disease of the gastrointestinal tract caused by Mycobacterium avium subspecies paratuberculosis (MAP). The aim of this study was to detect proteomic changes in peripheral blood mononuclear cells (PBMC) from cows of the same herd with different MAP infecti...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036881 | Pride
Paratuberculosis  mycobacteria  host-pathogen response  immune system  quantitative label-free lc-ms/ms  bovine 
ProteomicsAltered porcine PBMC proteome and secretome after stimulation with BanLec
With this experiment, we aimed at showing changes in the proteome and secretome of porcine peripheral blood mononuclear cells (PBMC) after stimulation with Banana Lectin (BanLec).
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-08-26 | PXD027505 | Pride
Pbmc Musa banana Polyclonal cell stimulation Banlec Plant lectin Pig Lc-ms/ms 
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