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ProteomicsAstrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions
Brain injury induces a peripheral acute cytokine response (ACR) that directs the transmigration of leukocytes into brain. This brain-to-peripheral immune communication affects patient recovery, thus understanding how it is regulated is important. Contrary to expectations it is not regulated by sym...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD006087 | Pride
Il-1beta Neuroinflammation Brain injury Extracellular vesicles 
MetabolomicsA neurotoxic cellular stress response linked to dark microglia and toxic lipid secretion

Microglia, the brain’s primary resident immune cells, can assume various phenotypes with diverse functional outcomes on brain homeostasis. In Alzheimer’s disease (AD), where microglia are a leading causal cell type, the identity of microglia subsets that drive neurodegeneration remains unresolved...

2024-12-20 | MTBLS11942 | MetaboLights
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