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Viruses are obligate parasites that depend on the cellular machinery for their propagation. Several viruses also incorporate cellular proteins that facilitate viral spread. Defining these cellular proteins is critical to decipher viral life cycles and delineate novel therapeutic strategies. While nu...
ORGANISM(S): Homo sapiens (Human) Human coronavirus OC43 
2024-06-24 | PXD052967 | Pride
Transcriptional profiling of N-Tera2 differentiated human neuronal cells, comparing control uninfected cells to HCoV-OC43 infected cells at 24, 48 and 72 hour post-infection Keywords: Cell response to viral infection Two-condition experiment, N-Tera2 differentiated human neuronal cell mock infected...
ORGANISM(S): Homo sapiens 
To explore host factors and pathways modulated by coronavirus infections, we performed global quantitative proteomics profiling. Huh7 cells were infected with SARS-CoV-2 (MOI=1.0), HCoV-229E (MOI=0.1), or HCoV-OC43 (MOI=1.0) for 24 hours, compared with MOCK infection. Protein samples were digested a...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057194 | Pride
DiMNF treated NHBE cells with HCoV-OC43 Infection
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex [A549]
Inhibition of coronavirus HCoV-OC43 by targeting the eIF4F complex [Vero E6]
Long term coinfection with hCOV-OC43 and Influenza A/H3N2 viruses
The transcriptional and translational landscape of HCoV-OC43 infection
The emergence of novel betacoronaviruses has posed significant financial and human health burdens, necessitating the development of appropriate tools to combat future outbreaks. In this study, we have characterized a human cell line, IGROV-1, as a robust tool to detect, propagate, and titrate betaco...
ORGANISM(S): Homo sapiens 
2023-09-19 | GSE237131 | GEO
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