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TranscriptomicsTetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization
The tetraspanin CD63 is implicated in pro-metastatic signaling pathways, but so far, it is unclear how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation in different metastatic tumor cell lines. In vitro, knock down of CD63 induced a more epithelial-lik...
ORGANISM(S): Homo sapiens 
2015-01-23 | E-GEOD-61957 | biostudies-arrayexpress
ProteomicsHEK293 CD63 CRISPR cell-derived small EVs
The tetraspanin protein CD63 has been recently described as a key factor in extracellular vesicle (EV) production and endosomal cargo sorting. In this study, we assemble a global scope of CD63-dependent protein trafficking into small secreted vesicles.
ORGANISM(S): Homo sapiens (Human) 
2018-10-24 | PXD006514 | Pride
Extracellular vesicles Tetraspanin Crispr Cd63 Lc-msms 
ProteomicsHuman - Cells and Extracellular vesicles of Hela and MNT-1 WT vs CD63 KO Proteomes 2
CD63 is a tetraspanin, which organize on cholesterol enriched microdomains, especially on late endosomes. Previous work of our team has shown that CD63 could regulate the sorting of cargoes into ILVs through an ESCRT-independent manner in melanocytes. However, CD63 has also been involved in other tr...
ORGANISM(S): Homo sapiens (Human) 
2024-04-19 | PXD037147 | Pride
Cd63 Extracellular vesicles (ev) Hela Mnt-1 Cell lines 
ProteomicsHuman - Cells and Extracellular vesicles of Hela and MNT-1 WT vs CD63 KO Proteomes 1
CD63 is a tetraspanin, which organize on cholesterol enriched microdomains, especially on late endosomes. Previous work of our team has shown that CD63 could regulate the sorting of cargoes into ILVs through an ESCRT-independent manner in melanocytes. However, CD63 has also been involved in other tr...
ORGANISM(S): Homo sapiens (Human) 
2024-04-19 | PXD037146 | Pride
Cd63 Extracellular vesicles (ev) Hela Mnt-1 Cell lines 
ProteomicsHuman - Cells and Extracellular vesicles of Hela and MNT-1 WT vs CD63 KO Exosomes
CD63 is a tetraspanin, which organize on cholesterol enriched microdomains, especially on late endosomes. Previous work of our team has shown that CD63 could regulate the sorting of cargoes into ILVs through an ESCRT-independent manner in melanocytes. However, CD63 has also been involved in other tr...
ORGANISM(S): Homo sapiens (Human) 
2024-04-19 | PXD037149 | Pride
Cd63 Extracellular vesicles (ev) Hela Mnt-1 Cell lines 
GenomicsCD63 regulates corneal epithelium abundant genes in the limbus
CD63 regulates corneal epithelium abundant genes in the limbus
PRJNA1329184 | ENA
ProteomicsCD63/CD9-GFP extracellular vesicles LC-MS/MS
This study aimed to identify subpopulations of extracellular vesicles (EVs) secreted by HeLa cells, and determine markers which enable to identify them, and which indicate their endosomal or plasma membrane origin. We used CD63 and CD9 as markers of EVs, and followed their intracellular trafficking ...
ORGANISM(S): Homo sapiens (Human) 
2021-05-17 | PXD021515 | Pride
Human Extracellular vesicles 
GenomicsGene expression changes upon CD63 knockdown in esophageal squamous cell carcinoma cell lines
Gene expression changes upon CD63 knockdown in esophageal squamous cell carcinoma cell lines
PRJNA1181548 | ENA
GenomicsCharacterization of CD63+ adult liver stem cells and downstream lineages
Characterization of CD63+ adult liver stem cells and downstream lineages
PRJNA885442 | ENA
TranscriptomicsCD63 regulates corneal epithelium abundant genes in the limbus
PURPOSE. Building on identification of ABCB5 as a limbal stem cell (LSC) marker, this study evaluates CD63, a newly identified LSC molecule co-expressed with ABCB5, in human limbal epithelial cells to elucidate its role in maintaining corneal epithelial identity. METHODS. RNA sequencing (RNA-seq) wa...
ORGANISM(S): Homo sapiens Mus musculus 
2026-03-18 | GSE308189 | GEO
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