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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
ProteomicsA cis-regulatory element controls HDAC9 expression to fine-tune inflammasome-dependent chronic inflammation
To understand the underlying molecular mechanism of Hdac9-mediated inflammasome activation and motivated by the molecular scaffolding function of HDAC9, we pursued the hypothesis that HDAC9 may serve as a docking site for cytosolic inflammasome components thereby facilitating its rapid formation upo...
ORGANISM(S): Homo sapiens (Human) 
2025-07-10 | PXD042078 | Pride
Inflammation Inflammasome Atherosclerosis Hdac9 Nlrp3 
TranscriptomicsA Dach2-Hdac9-Myog-Gdf5 signaling system regulates regeneration of neuromuscular synapses
Muscle denervation due to injury, disease or aging results in impaired motor function. Restoring neuromuscular communication requires axonal regrowth and regeneration of neuromuscular synapses. Muscle activity inhibits neuromuscular synapse regeneration. The mechanism by which muscle activity regu...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-58669 | biostudies-arrayexpress
GenomicsGene expression in HDAC8 and HDAC9 silencing keratinocyte
Gene expression in HDAC8 and HDAC9 silencing keratinocyte
PRJNA645303 | ENA
GenomicsLiver RNA microarray from female HDAC6–/–, HDAC9–/– mice
Liver RNA microarray from female HDAC6–/–, HDAC9–/– mice
PRJNA494561 | ENA
GenomicsHDAC9 Complex Inhibition Improves Smooth Muscle Dependent Arterial Stenosis
HDAC9 Complex Inhibition Improves Smooth Muscle Dependent Arterial Stenosis
PRJNA492933 | ENA
GenomicsExpression data with inducible silencing of HDAC9 in human mesenchymal stem cells (hMSCs)
Expression data with inducible silencing of HDAC9 in human mesenchymal stem cells (hMSCs)
PRJNA705965 | ENA
TranscriptomicsMicroarray analysis of gene expression in HDAC9-knockdown macrophages.
To investigate the role of HDAC9 in innate immnue, we measured the gene expression profile in HDAC9-knockdown macrophages in the absence of innate stimuli by gene-chip in order to find wherther HDAC9 knockdown affect the innate immune factor. We found knockdown of HDAC9 barely affected transcription...
ORGANISM(S): Mus musculus 
2016-11-06 | GSE74749 | GEO
TranscriptomicsDeregulated expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma in mice [HDAC9 transgenic]
Histone deacetylase 9 (HDAC9) is expressed in B cells, and its overexpression has been observed in B-lymphoproliferative disorders, including B-cell non-Hodgkin lymphoma (B-NHL). We examined HDAC9 protein expression and copy number alterations in primary B-NHL samples, identifying high HDAC9 express...
ORGANISM(S): Mus musculus 
2016-11-17 | GSE89954 | GEO
GenomicsRNA-Seq analysis HDAC9 knockdown effect on vascular smooth muscle cells
RNA-Seq analysis HDAC9 knockdown effect on vascular smooth muscle cells
PRJNA950380 | ENA
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