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CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
Polycomb Repressive Complex 2 (PRC2) is an essential chromatin regulator responsible for mono-, di- and tri- methylating H3K27. Control of PRC2 activity is a critical process in development and disease. While PRC2 is inhibited in germinal cells, no inhibitory cofactor has been identified in somatic ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-26 | PXD053693 | Pride
Protein was extracted from the aortic media of 8-week-old SMC-CemipKO and Cemipflox/flox mice. Whole-cell lysates were immunoprecipitated with anti-MLC20 antibodies for proteomic analysis. Mass spectrometry identified top 10 MLC20-binding proteins as listed.
ORGANISM(S): Mus Musculus 
2025-03-18 | PXD062008 |
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