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ProteomicsProteome and Modification of Stat3 and Malt1 dependent on Hectd3
We transfected HEK293T cells with HA-Ub, Flag-Stat3 or Flag-Malt1A, with or without Xpress-Hectd3. We performed Flag immunoprecipitation then conducted LC-MS/MS.
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011756 | Pride
Th17 cells Eae Hectd3 Stat3 activation Multiple sclerosis K29-lniked polyubiquitin chain Malt1 Neuroinflammation Ubiquitination Pstat3 y705 K27-linked polyubiquitin chain Stat3 phosphorylation Stat3 
ProteomicsThe E3 ubiquitin ligase HectD3 is a novel regulator of cardiac hypertrophy and inflammation
The HECT domain E3 ubiquitin protein ligase 3 (HectD3) is highly expressed in the heart, but its cardiac function is still unknown. Here, we identified SUMO2 and Stat1 as novel cardiac substrates for HectD3. SUMO2 is a potent inducer of Calcineurin-NFAT mediated cardiomyocyte hypertrophy, whereas, S...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-09-09 | PXD020843 | Pride
Ubiquitin ligase Cardiac models Proteomics 
GenomicsThe E3 ubiquitin ligase Hectd3 controls immune colonic inflammation by restricting Myd88 signaling
The E3 ubiquitin ligase Hectd3 controls immune colonic inflammation by restricting Myd88 signaling
PRJNA1177405 | ENA
ProteomicsHECTD3 is a small HECT E3 ligase with unique features
HECT E3 ligases regulate many cellular processes, yet how they recognise their substrates and synthesise specific types of poly-ubiquitin chains is still incompletely understood. HECTD3, a member of the “other HECT” family, is implicated in the regulation of inflammation, apoptosis, and infection an...
ORGANISM(S): Homo sapiens (Human) 
2026-01-15 | PXD066996 | Pride
E3 ligase Cross-linking 
GenomicsRNA sequencing of HECTD3 knockdown during TNFalpha stimulation in primary HUVEC cells
RNA sequencing of HECTD3 knockdown during TNFalpha stimulation in primary HUVEC cells
PRJNA832954 | ENA
GenomicsNext Generation Sequencing Analysis of WT and Hectd3–/– BMDMs during F. novicida infection
Next Generation Sequencing Analysis of WT and Hectd3–/– BMDMs during F. novicida infection
PRJNA411777 | ENA
TranscriptomicsThe E3 ubiquitin ligase Hectd3 controls immune colonic inflammation by restricting Myd88 signaling
Ubiquitination is an important post-translational modification associated with essential cellular processes and implicated in regulation of immunity. Here we show that deletion of the E3 ubiquitin ligase Hectd3 systemically, or in hematopoietic compartment, including in CD11c+ cells, causes a more s...
ORGANISM(S): Mus musculus 
2026-08-17 | GSE280228 | GEO
GenomicsEffect of HectD3 overexpression on gene expression in neonatal rat cardiomyocytes
Effect of HectD3 overexpression on gene expression in neonatal rat cardiomyocytes
PRJNA655508 | ENA
TranscriptomicsNext Generation Sequencing Analysis of WT and Hectd3–/– BMDMs during F. novicida infection
Purpose: The goals of this study are to compare NGS-derived WT and Hectd3–/– transcrip profiling (RNA-seq) in the absence and presence of F. novicida infection Methods: Bone marrow derived macrophages (BMDMs) from WT and Hectd3–/– mice were infected with F .novicida for 8 and 12 hours. mRNA profiles...
ORGANISM(S): Mus musculus 
2018-06-15 | GSE104127 | GEO
UnknownTargeting HECTD3-IKKα axis inhibits inflammation-related metastasis.
Not available
S-EPMC9345961 | biostudies-literature
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