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TranscriptomicsConcerted action of Helios and Ikaros balances the strength of B cell receptor signaling and controls the expression of inositol 5-phosphatase SHIP
Inositol 5-phosphatase SHIP is differentially expressed in Ikaros and Helios deficient cells. In the absense of Ikaros SHIP is upregulated where as in the absense of Helios it is downregulated. Ikaros binds to the promoter of the SHIP gene. Article provides insight into the mechanisms of action Ikar...
ORGANISM(S): Gallus gallus 
2010-07-19 | E-GEOD-20946 | biostudies-arrayexpress
GenomicsArthrobacter sp. Helios
Arthrobacter sp. Helios Genome sequencing
PRJNA722834 | ENA
TranscriptomicsInfluence of ATL-type Helios overexpression or WT-Helios/Ikaros knockdown on gene expression profile in Jurkat cells
It has been known that aberrant isoforms of Ikaros family ptoteins are expressed in malignant cells. We identified that PBMC of ATL (acute T-cell leukemia) patients expresses different patterns of Helios isoforms compared with normal PBMC. In order to investigate the biological impact of ATL-type He...
ORGANISM(S): Homo sapiens 
2013-03-31 | E-GEOD-41796 | biostudies-arrayexpress
GenomicsExiguobacterium sp. Helios
Exiguobacterium sp. Helios Assembly
PRJNA632476 | ENA
ProteomicsRedirecting the neo-substrate specificity of Cereblon-targeting PROTACs to Helios
Immunomodulatory imide drugs (IMiDs), such as thalidomide and its analogues, are some of the most commonly utilized E3 ligase ligands for the development of proteolysis targeting chimeras (PROTACs). While the canonical neo-substrates of IMiDs (i.e., Ikaros and Aiolos) are often considered to be unwa...
ORGANISM(S): Homo sapiens (Human) 
2022-09-07 | PXD036170 | Pride
Targeted protein degradation Degrader Helios Cdk4 Protac Cdk6 
GenomicsChIP-seq HELIOS (Ikzf2)
ChIP-seq HELIOS (Ikzf2)
PRJNA627719 | ENA
ProteomicsReprogramming the E3 ubiquitin ligase CRL4CRBN to degrade Helios
The zinc finger transcription factor Helios is critical for maintaining the identity and suppressive phenotype of regulatory T cells (Tregs) and as such is an attractive target to enhance the efficacy of currently approved immunotherapies. However, no small molecules exist which can directly modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-05-26 | PXD016168 | Pride
Imide Crl4 Molecular glue Crbn Ubiquitin Tregscrl4 Helios 
ProteomicsReprogramming the E3 ubiquitin ligase CRL4CRBN to degrade Helios
The zinc finger transcription factor Helios is critical for maintaining the identity and suppressive phenotype of regulatory T cells (Tregs) and as such is an attractive target to enhance the efficacy of currently approved immunotherapies. However, no small molecules exist which can directly modulat...
ORGANISM(S): Homo sapiens (Human) 
2021-05-26 | PXD023691 | Pride
Imide Tregs Crl4 Molecular glue Crbn Ubiquitin Helios 
GenomicsChIP-seq IKAROS (Ikzf1) and HELIOS (Ikzf2)
ChIP-seq IKAROS (Ikzf1) and HELIOS (Ikzf2)
PRJNA1309047 | ENA
UnknownExpected and observed in-hospital mortality in heart failure patients before and during the COVID-19 pandemic: Introduction of the machine learning-based standardized mortality ratio at Helios hospitals.
Not available
S-EPMC8799043 | biostudies-literature
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