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ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
Global quantitative proteomics of cells treated with the immunomodulatory drug pomalidomide or dipeptide degrons; global quantitative proteomics of cells treated with heterobifunctional degraders embedded with thalidomide or cyclic imide degrons; gloabl quantitative proteomics of red blood cells to ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD025413 | Pride
Degron Cereblon Cyclic imide Imid E3 
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
The E3 ligase factor cereblon (CRBN) is a target of thalidomide and lenalidomide, which are therapeutic agents used in the treatment of hematopoietic malignancies and as ligands for targeted protein degradation. These agents are proposed to mimic a naturally occurring degron; however, the structural...
ORGANISM(S): Homo sapiens (Human) 
2022-07-28 | PXD034248 | Pride
Degron Cyclic imide Cereblon Protac 
ProteomicsThe E3 ubiquitin ligase adaptor cereblon targets the C-terminal cyclic imide degron
We identify cyclic imides, previously overlooked post-translation modifications, across different tissues (red blood cells and bovine lens) and human-derived cell lines and found that these modifications are globally regulated by cereblon.
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2022-07-28 | PXD030091 | Pride
Degron Lc-ms/ms Cyclic imide Cereblon Ptm 
ProteomicsPCMT1 generates the C-terminal cyclic imide degron on CRBN substrates
The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can form spontaneously, an enzyme that regulates the formation of ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-12-05 | PXD061730 | Pride
Crbn Pcmt1 C-terminal cyclic imide Glul Ppa1 
UnknownAmmonia decomposition catalysis using non-stoichiometric lithium imide.
Not available
S-EPMC5707451 | biostudies-literature
UnknownThermophysical Study of 1-Butyl-2-methylpyridinium bis(trifluoromethylsulfonyl)imide and 1-Butyl-4-methylpyridinium bis(trifluoromethylsulfonyl)imide.
Not available
S-EPMC11573118 | biostudies-literature
UnknownSynthesis and characterization of three-coordinate Ni(III)-imide complexes.
Not available
S-EPMC3192028 | biostudies-literature
UnknownTemperature-Dependent Electrochemical Stability Window of Bis(trifluoromethanesulfonyl)imide and Bis(fluorosulfonyl)imide Anion Based Ionic Liquids.
Not available
S-EPMC9247390 | biostudies-literature
UnknownDynamic Polyamide Networks via Amide-Imide Exchange.
Not available
S-EPMC8552437 | biostudies-literature
UnknownNature of the Lithium Amide-Imide Catalyst System under Ammonia Decomposition Conditions.
Not available
S-EPMC12536390 | biostudies-literature
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