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ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD055254 | Pride
Dia Ipsc Label-free Human Cortical tissue model 
ProteomicsProteomic analysis of a novel iPSC-derived 3D brain tissue model (3BTM) of Alzheimer’s disease
Stem-cell-based in vitro models offer promising potential to elucidate pathomechanisms underlying neurological diseases such as Alzheimer’s disease. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models and lack of AD-relevant pa...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071849 | Pride
3d brain tissue model Alzheimer’s disease 3btm Brain Ipsc 
ProteomicsProteomics of tumor associated microglia, tumor tissue from SB28 glioblastoma mice, and control microglia
The 18 kDa translocator protein (TSPO) emerges as an important PET biomarker to assess the tumor microenvironment (TME) in glioblastoma. However, various cellular sources hamper interpretation and biological understanding of TSPO and other immune biomarkers in the TME. Thus, we established a novel m...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-30 | PXD044033 | Pride
Tumor tissue Microglia Tumor associated microglia Sb28 glioblastoma 
ProteomicsAssessing inter-line reproducibility of a novel iPSC-derived 3D brain tissue model (3BTM) and comparison to 2D co-cultures
Stem-cell-based in vitro models offer promising potential to elucidate human brain cell functions and interactions under healthy conditions and in disease states. However, harnessing this potential is currently impaired by low reproducibility, maturity, and cell-type diversity of models. Therefore, ...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD069984 | Pride
3d brain tissue model 3btm Brain Ipsc 
GenomicsGlioma_Exome_FRE_CASES - samples
French glioma case germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000758 | EGA
GenomicsGlioma_Exome_UK_CASES - samples
UK glioma case germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000754 | EGA
GenomicsGlioma_Exome_FRE_CONTROLS - samples
French glioma control germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000756 | EGA
GenomicsGlioma_Exome_GER_CASES - samples
German glioma case germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000752 | EGA
GenomicsGlioma_Exome_GER_CONTROLS - samples
German glioma control germline genotypes using Illumina HumanExome-12v1_A array
EGAD00010000750 | EGA
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