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ProteomicsSLP76 interactome in resting and activated primary mast cells
We used a knock-in (KI) mouse expressing SLP-76 with a C-terminal One-Strep-Tag (OST). Such a system allowed the replacement in the genome of SLP-76 by its tagged version and its expression in physiological amounts. Then, by combining high affinity purification and label-free quantitative proteomics...
ORGANISM(S): Mus musculus (Mouse) 
2013-08-28 | PXD000052 | Pride
Interactomics Slp76 Quantitative mass spectrometry 
ProteomicsCK2β is a gatekeeper of focal adhesions regulating cell spreading
CK2 is an hetero-tetrameric protein made of two CK2α catalytic subunits and two regulatory CK2β subunits. The free CK2α subunit and the tetrameric holoenzyme have distinct substrate specificity profiles suggesting that the spatiotemporal organization of the individual CK2 subunits observed in living...
ORGANISM(S): Homo sapiens (Human) 
2022-07-05 | PXD030991 | Pride
Proteomics Tyrosine phosphorylated proteins Ck2β depletion Lc-ms/ms 
ProteomicsA Specific RAGE Phosphorylation by CK2 in human Amniotic Epithelial cell model
The receptor for advanced glycation end products (RAGE) is a multiligand, immunoglobulin-like transmembrane protein expressed in various cell types and implicated in a broad spectrum of diseases linked with epithelial dysfunctions. Despite significant progress in structural studies, the details of i...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD064008 | Pride
Rage / ck2 / phosphorylation 
ProteomicsProteomic analysis of subchloroplastic compartments
Arabidopsis thaliana chlorosplasts extraction followed by subchloroplastic compartments fractionation (envelope, stroma, thylakoids). Afer SDS-PAGE separation and trypsin digestion, analysis of all gel bands twice by LC-MS/MS on a LTQ-FT
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2016-12-23 | PXD000136 | Pride
Sub compartments fractionation Chloroplast Ltq-ft Lc-ms/ms 
ProteomicsRibosomal protein signature in adult mouse organs
we purified the ribosomal fraction from 14 different adult mouse tissues and analyzed their protein composition using quantitative mass spectrometry (MS)-based proteomics. We show that ribosomes exhibit heterogeneity in RP composition, not only in the case of RP paralogues (e.g. in muscle and testis...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD044060 | Pride
Ribosome Mouse Quantification Lc-ms/ms 
ProteomicsGuidance landscapes unveiled by quantitative proteomics to control reinnervation in adult visual system
Long-distance regeneration of the central nervous system (CNS) has been achieved from the eye to the brain through activation of neuronal molecular pathways or pharmacological approaches. Characterizing the mature neuronal environment is essential to understand the adult axonal guidance in order to ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-20 | PXD029325 | Pride
Lc-ms/ms Qexactive hf Cns Mouse 
ProteomicsRibosomal protein L5 (RPL5/uL18) I60V mutation is associated to increased translation and modulates drug sensitivity in T-cell acute lymphoblastic leukemia cells
Somatic mutations in ribosomal proteins (RPs), including RPL5, have been reported in approximately 10% of pediatric patients with T-cell acute lymphoblastic leukemia (T-ALL). In cancer, the incorporation of mutant RPs into ribosomes often disrupts canonical ribosome function, thereby contributing to...
ORGANISM(S): Homo sapiens (Human) 
2025-11-06 | PXD064727 | Pride
Ribosomes Target therapy Cancer Lc-ms/ms 
ProteomicsDeciphering thylakoid microdomains using a mass spectrometry-based approach
In photosynthetic eukaryotes, photosynthesis occurs in the chloroplast, and more specifically in the thylakoid membranes. The thylakoids consist of two main domains: the grana, which are piles of membranes gathered together by stacking forces, and the stroma-lamellae, which are unstacked thylakoids ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2015-09-23 | PXD000546 | Pride
Clustering Grana Chloroplast Thylakoid Stroma-lamellae Statistical analysis Subcellular localization Label-free quantitation 
ProteomicsProline: an efficient and user-friendly software suite for large-scale proteomics
We present Proline (http://www.profiproteomics.fr/proline/), a robust software suite for analysis of MS-based proteomics data; it provides high performance in a user-friendly interface for all data set sizes from small to very large
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-03-03 | PXD009815 | Pride
Label free quantification data management software proline 
ProteomicsPlasma ALS and LG3BP predict liver fibrosis in NAFLD patients
Non-alcoholic fatty liver disease (NAFLD) is estimated to affect 25% of the world’s population and its prevalence is increasing with the rise in obesity. The evolution of this disease includes different pathological stages: steatosis, inflammation, fibrosis, cirrhosis and hepatocellular carcinoma (H...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD043340 | Pride
Plasma nafld biomarkers discovery 
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