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ProteomicsComplete loss of H3K9 methylation dissolves mouse heterochromatin organization
Histone H3 lysine 9 (H3K9) methylation is a central epigenetic modification that defines heterochromatin from unicellular to multicellular organisms. In mammalian cells, H3K9 methylation can be catalyzed by at least six distinct SET domain enzymes: Suv39h1/Suv39h2, Eset1/Eset2 and G9a/Glp. We used m...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-27 | PXD018175 | Pride
Repeat silencing Heterochromatin organization Histone methyltransferases Proteomic quantification of h3k9 methylation Genome stability 
GenomicsLeo1 is a Global Regulator of Heterochromatin Cis-spreading
Domains of heterochromatin play important roles in the maintenance and regulation of eukaryotic genomes. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates the existence of robust mechanisms that limit heterochromatin spreading and thereby a...
ORGANISM(S): Schizosaccharomyces pombe 
2015-05-22 | E-GEOD-61688 | biostudies-arrayexpress
TranscriptomicsNuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly
RNAseIII ribonucleases act at the heart of RNA silencing pathways by processing precursor RNAs into mature microRNAs and siRNAs. In the fission yeast Schizosaccharomyces pombe, siRNAs are generated by the RNAseIII enzyme Dcr1 and are required for heterochromatin formation. In this study, we have ana...
ORGANISM(S): Schizosaccharomyces pombe 
2010-02-16 | E-GEOD-18582 | biostudies-arrayexpress
TranscriptomicsMolecular landscape of modified histones in Drosophila heterochromatin
The aim of this study is to analyze the distribution of the modified histones in and around peri-centromeric heterochromatin at high resolutions for understanding the molecular nature of the heterochromatic genes and euchromatin-heterochromatin transition. Since heterochromatin is repeat-rich, strin...
ORGANISM(S): Drosophila melanogaster 
2010-06-29 | E-GEOD-7839 | biostudies-arrayexpress
GenomicsThe Histone Variant H2A.W Defines Heterochromatin and Promotes Chromatin Condensation in Arabidopsis
Histone variants play crucial roles in gene expression, genome integrity and chromosome segregation. However, to what extent histone variants control chromatin architecture remains largely unknown. Here, we show that the previously uncharacterized histone variant H2A.W plays a crucial role in conde...
ORGANISM(S): Arabidopsis thaliana 
2014-07-05 | E-GEOD-50942 | biostudies-arrayexpress
ProteomicsDrosophila HP1a IP-MS - The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic
Heterochromatin is enriched for characteristic epigenetic factors, including Heterochromatin Protein 1a (HP1a) and is essential for many organismal functions. However, how this nuclear domain is organized and functions is unclear. We extensively investigated heterochromatin protein compostion by bio...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2016-08-18 | PXD003780 | Pride
Heterochromatin protein 1a Drosophila melanogaster 
TranscriptomicsHigh resolution Hi-C analysis in S. pombe reveals fundamental elements of genome architecture (NGS)
Eukaryotic genomes are folded into a hierarchy of three-dimensional structures that impact nuclear functions, including transcription, replication, and repair1-3. Studies in Drosophila and mammals have revealed megabase-sized topologically associated domains (TADs) within chromosomes, which in turn ...
ORGANISM(S): Schizosaccharomyces pombe 
2014-10-22 | E-GEOD-57316 | biostudies-arrayexpress
GenomicsLoss of neuronal 3D chromatin organization causes transcriptional and behavioral deficits related to serotonergic dysfunction [ChIP-seq]
The interior of the neuronal cell nucleus is a highly organized 3-dimensional (3D) structure in which regions of the genome that are millions of bases apart participate in specialized sub-structures with dedicated functions. To investigate neuronal chromatin organization and dynamics in vivo, we gen...
ORGANISM(S): Mus musculus 
2014-07-18 | E-GEOD-56809 | biostudies-arrayexpress
GenomicsForced expression of MSR repeat transcripts breaks heterochromatin organization
Forced expression of MSR repeat transcripts breaks heterochromatin organization
PRJNA1091166 | ENA
ProteomicsMBD2 modulates heterochromatin architecture and composition
Heterochromatin (HC) is essential for nuclear integrity, genome stability, and gene regulation with pericentric heterochromatin (PCH) playing a key role. However, the mechanisms governing PCH compartmentalization remain poorly understood. Recent studies suggest that phase separation (PS) underlies t...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD055626 | Pride
Mice brain Dia-ms Mbd2 Pericentric heterochromatin Alphafold server Nuclear fractionation Ps prediction tools Phase separation 
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