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ProteomicsTargeting LSD1 rewires kinase networks and primes leukaemia cells for kinase inhibitor treatment
We show that intrinsic resistance to kinase inhibitors may be reversed by coercing kinase networks into acquiring topologies tolerant to drug sensitivity. Using acute myeloid leukaemia (AML) as a model, we found several antagonists of chromatin modifying enzymes that sensitised cancer cells to kinas...
ORGANISM(S): Homo sapiens (Human) 
2022-04-25 | PXD018603 | Pride
Phosphoproteomics Kinase signaling networks Lsd1 Acute myeloid leukaemia Bioinformatics 
ProteomicsTumour Endothelial Cell Reprogramming Orchestrates Angiocrine Signalling to Drive Chemoresistance in Breast Cancer
Phosphoproteomic analysis was performed to decipher changes occurring in tumour cells after treatment with conditioned media from endothelial cells, which may protect them from doxorubicin damage, and promote resistance to the treatment. Briefly, MMTV-PyMT (mouse mammary tumour virus-polyoma middle ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-29 | PXD070990 | Pride
Doxorubicin Phosphoproteomics Angiocrine Chemoresistance Lc-ms/ms 
ProteomicsMind Your Spectra: Points to be Aware of when Validating the Identification of Isobaric Histone Peptidoforms
Mass spectrometry (MS) is now well recognized as a powerful technique to identify and quantify post-translational modifications (PTMs), overcoming many of the limitations of antibody-based methods. Histones, which play a central role in all DNA-templated processes, are regulated by a wealth of dynam...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-22 | PXD057347 | Pride
Histone h3 variants Acylations Overpropionylation Isobaric peptides 
ProteomicsMind Your Spectra: Points to be Aware of when Validating the Identification of Isobaric Histone Peptidoforms
Mass spectrometry (MS) is now well recognized as a powerful technique to identify and quantify post-translational modifications (PTMs), overcoming many of the limitations of antibody-based methods. Histones, which play a central role in all DNA-templated processes, are regulated by a wealth of dynam...
ORGANISM(S): Mus Musculus 
2025-10-17 | PXD057376 | panorama
UnknownTaming type III achalasia and coexisting diverticula with complex surgical history with peroral endoscopic myotomy.
Not available
S-EPMC12009083 | biostudies-literature
UnknownMeta-analysis of the efficacy and safety of vamorolone in Duchenne muscular dystrophy.
Not available
S-EPMC12003609 | biostudies-literature
UnknownCommunity detection in empirical kinase networks identifies new potential members of signalling pathways.
Not available
S-EPMC10325051 | biostudies-literature
UnknownAn update on post-translational modifications of hydroxyproline-rich glycoproteins: toward a model highlighting their contribution to plant cell wall architecture.
Not available
S-EPMC4132260 | biostudies-literature
UnknownPlanarian MBD2/3 is required for adult stem cell pluripotency independently of DNA methylation.
Not available
S-EPMC3824064 | biostudies-literature
UnknownRole of community pharmacists in weight management: results of a national study in Lebanon.
Not available
S-EPMC7204056 | biostudies-literature
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