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GenomicsSRC-1 targets ADAM22: an ER-independent mechanism of tumour progression in endocrine resistance
We profile the binding of Steroid Receptor Co-activator (SRC1) in LY2 cells, a tamoxifen-resistant cell line, in the presence and absence of tamoxifen using ChIP-sequencing technology. The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity le...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28987 | biostudies-arrayexpress
TranscriptomicsSRC1 gene regulation in endocrine resistant breast cancer cells
The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid independent tumour. The p160 steroid coactivator protein SRC-1, through interactions with developmental proteins and other non-steroidal transcrip...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-28645 | biostudies-arrayexpress
UnknownPooled solifenacin overactive bladder trial data: Creation, validation and analysis of an integrated database.
Not available
S-EPMC5935888 | biostudies-literature
ProteomicsERK signaling promotes IKKepsilon expression and oncogenic functions in pancreatic cancer cells in association with TBK1
A variety of cancers utilize RAS-regulated signaling pathways to promote oncogenic phenotypes. A widely studied example is pancreatic cancer, where mutant KRAS signaling leads to activation of MEK/ERK kinases and downstream signaling which promotes oncogenic mechanisms, including cell proliferation....
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD060883 | Pride
Erk Ikkepsilon Mapk Tbk1 Kras 
TranscriptomicsTranscription profiling of developmental time series for 10 different mutants with a combination of single and double mutants in 6 genes
We analyzed a developmental time course of ten different mutants with a combination of single and double mutants in 6 genes. The samples were collected at the following time points following starvation: 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22 and 24 hours. Dissimilarities between mutant time cours...
ORGANISM(S): Dictyostelium discoideum 
2005-04-08 | E-TABM-6 | biostudies-arrayexpress
ProteomicsBasal Proteomics of T-cell lymphoma cell cultures
This dataset contains shotgun LC-MS/MS proteomic data from 30 established T- and NK-cell-derived lymphoma cell cultures. These data were collected to quantify baseline protein abundance across in vitro models of peripheral T- and NK-cell lymphomas. In downstream analyses we identified correlations b...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD075893 | Pride
T-cells Lymphoma Human Astral Crispr 
UnknownUnderstanding patterns of fatigue in health and disease: protocol for an ecological momentary assessment study using digital technologies.
Not available
S-EPMC11131111 | biostudies-literature
MetabolomicsMapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum
Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...
2020-12-02 | MTBLS1188 | MetaboLights
TranscriptomicsGene expression profiling of fathead minnows (Pimephales promelas) following an acute exposure to pulp and paper mill effluents
We evaluated the possible mechanisms by which exposure to a sequentially treated pulp and paper mill effluent affects gene expression in the liver of male and female fathead minnows. Sexually mature fathead minnows were exposed to either river water, which served as our control (C), 10% untreated kr...
ORGANISM(S): Pimephales promelas 
2012-12-31 | E-GEOD-25928 | biostudies-arrayexpress
MetabolomicsThe impact of nutritional supplementation on sweat metabolomic content
Sweat is emerging as a prominent biosource for real-time human performance monitoring applications. Although promising, sources of variability must be identified to truly utilize sweat for biomarker applications. In this proof-of-concept study, a targeted metabolomics method was applied to sweat col...
2021-03-15 | MTBLS2427 | MetaboLights
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