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TranscriptomicsTranscription profiling of mouse wild type (wt) and Ikbke knockout (Ikke) embryonic fibroblasts (EF)
WT and Ikbke-/- EF cells were stimulated with recombinant interferon beta for 6 hours. Cells lacking IKKe kinase show a defect in a subset of interferon stimulated gene transcription Experiment Overall Design: WT and Ikbke cells were either stimulated and left untreated to compare their response to...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6837 | biostudies-arrayexpress
UnknownPredicting and validating a model of suppressor of IKKepsilon through biophysical characterization.
Not available
S-EPMC6635840 | biostudies-literature
ProteomicsSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and alpha-actinin, linking innate immunity to the cytoskeleton
Suppressor of IKKepsilon (SIKE) is associated with the innate immune system’s type I interferon response through TANK binding kinase 1 (TBK1). Characterized as an endogenous inhibitor of TBK1 when overexpressed in viral infection and pathological cardiac hypertrophic models, mechanistic study revea...
ORGANISM(S): Homo sapiens (Human) 
2018-05-29 | PXD007262 | Pride
Innate immunity Cytoskeleton Sike Tubulin Alpha-actinin 
ProteomicsERK signaling promotes IKKepsilon expression and oncogenic functions in pancreatic cancer cells in association with TBK1
A variety of cancers utilize RAS-regulated signaling pathways to promote oncogenic phenotypes. A widely studied example is pancreatic cancer, where mutant KRAS signaling leads to activation of MEK/ERK kinases and downstream signaling which promotes oncogenic mechanisms, including cell proliferation....
ORGANISM(S): Homo sapiens (Human) 
2025-08-05 | PXD060883 | Pride
Erk Ikkepsilon Mapk Tbk1 Kras 
UnknownSuppressor of IKKepsilon forms direct interactions with cytoskeletal proteins, tubulin and α-actinin, linking innate immunity to the cytoskeleton.
Not available
S-EPMC6026704 | biostudies-literature
UnknownRegulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.
Not available
S-EPMC2441564 | biostudies-literature
UnknownUse of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation.
Not available
S-EPMC2682862 | biostudies-literature
UnknownUbiquitin-regulated recruitment of IkappaB kinase epsilon to the MAVS interferon signaling adapter.
Not available
S-EPMC2698723 | biostudies-literature
UnknownHepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion.
Not available
S-EPMC2904777 | biostudies-literature
UnknownKnock-Out of IKKepsilon Ameliorates Atherosclerosis and Fatty Liver Disease by Alterations of Lipid Metabolism in the PCSK9 Model in Mice.
Not available
S-EPMC11476531 | biostudies-literature
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