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TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
ProteomicsRegulation of mammalian 3D genome organization and histone H3K9 dimethylation by H3K9 methyltransferases
Histone H3 lysine 9 dimethylation (H3K9me2) is a highly conserved silencing epigenetic mark. Chromatin marked with H3K9me2 forms large domains in mammalian cells and overlaps well with lamina-associated domains and the B compartment defined by Hi-C. However, the role of H3K9me2 in 3-dimensional (3D)...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-05 | PXD024756 | Pride
Histone h3 methylation 
Transcriptomics5-azacytidine treatment reorganizes genomic histone modification patterns
Methylation of DNA in combination with histone modifications establishes an epigenetic code that ensures the proper control of gene expression. Although DNA methyltransferases have been shown to interact with histone methyltransferases such as EZH2 (which methylates histone H3 on lysine 27) and G9a ...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-20598 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (Dnmt3ab KO ChIP-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47878 | biostudies-arrayexpress
TranscriptomicsdKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing.
Transcription regulation involves enzyme-mediated changes in chromatin structure. Here, we describe a novel mode of histone crosstalk during gene silencing, in which histone H2A monoubiquitylation is coupled to the removal of histone H3 Lys 36 dimethylation (H3K36me2). This pathway was uncovered thr...
ORGANISM(S): Drosophila melanogaster 
2011-12-13 | E-GEOD-34390 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of pituitary glands from wild type and LSD1 knock-out mice
Precise control of transcriptional programs underlying metazoan development is modulated by enzymatically active co-regulatory complexes, coupled with epigenetic strategies, but how specific members of histone modification enzyme families such as histone methyltransferases and demethylases are utili...
ORGANISM(S): Mus musculus 
2007-02-13 | E-TABM-223 | biostudies-arrayexpress
GenomicsMaintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO ChIP-Seq)
During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of...
ORGANISM(S): Mus musculus 
2014-06-03 | E-GEOD-47887 | biostudies-arrayexpress
ProteomicsAntagonistic roles of histone 3 lysine methyltransferases dictate tumor immune surveillance
Histone H3 lysine 36 (H3K36) methyltransferases are frequently mutated in cancer, but their functional roles remain unclear. Using functional genomics approaches within KRAS-driven lung cancer models, we show that NSD2, SETD2, and EZH2 work in concert to regulate expression of endogenous retroviral ...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-22 | PXD069619 | Pride
Nsd2 Epigenetic vulnerability Immune surveillance Chromatin regulation Ervs Kras lung cancer H3k36 methylation Ezh2 Setd2 H3k36m 
UnknownTargets of histone H3 lysine 9 methyltransferases.
Not available
S-EPMC9768651 | biostudies-literature
GenomicsThe Histone Methyltransferase Wbp7 Controls Macrophage Function through GPI Glycolipid Anchor Synthesis. [ChIP_seq]
Histone methyltransferases catalyze site-specific deposition of methyl groups, enabling recruitment of transcriptional regulators. In mammals, trimethylation of lysine 4 in histone H3, a modification localized at the transcription start sites of active genes, is catalyzed by six enzymes (SET1a and S...
ORGANISM(S): Mus musculus 
2012-04-09 | E-GEOD-30972 | biostudies-arrayexpress
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